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Toxicity study of Schiff bases derived from 2,6-diaminopyridine and their novel metal complexes

机译:2,6-二氨基吡啶及其新型金属配合物源自Schiff碱的毒性研究

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Two Schiff bases (L1∶C19H15N3O2 and L3∶C21H19N3O6) derived from 2,6-diaminopyridine with salicylaldehyde and o-vanillin, respectively, were successfully synthesized and characterized. Four novel metal complexes of these ligands with Zn(II) and Cd(II) namely ZnL1, ZnL3, CdL1 and CdL3 were obtained and the chemical structures were investigated by means of elemental analysis, FTIR, conductivity and magnetic susceptibility measurements. All the complexes were diamagnetic, displayed ν(C=N) bands in the range 1599–1615 cm−1 and non-electrolytic in solution. The toxicity of the Schiff base ligands and their novel metal complexes was studied from the viability of treated human neuroblastoma SH-SY5Y cell lines.
机译:两个Schiff基地(L1∶ C 19 H 15 N 3 O 2 和L3∶ c 21 H 19 N 3 O 6 )衍生自2,6-二氨基吡啶与水杨醛和O-VANILLIN, 分别成功合成并表征。 获得具有Zn(II)和Cd(II)的这些配体的四种新型金属络合物,即ZnL1,ZnL3,CDL1和CDL3,通过元素分析,FTIR,电导率和磁性敏感性测量研究了化学结构。 所有复合物都是抗磁的,显示的ν(c = n)条带,范围为1599-1615cm − 1 和溶液中的非电解。 从处理的人神经母细胞瘤SH-SEN-SEC-SER5Y细胞系的可行性研究了Schiff碱配体及其新型金属配合物的毒性。

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