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首页> 外文会议>Annual Conference of the American^Association^of^Bovine^Practitioners., Conference >A randomized controlled clinical trial to evaluate the effect of an intranasal respiratory vaccine on calf health, ultrasonographic lung consolidation, and growth in Holstein dairy calves
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A randomized controlled clinical trial to evaluate the effect of an intranasal respiratory vaccine on calf health, ultrasonographic lung consolidation, and growth in Holstein dairy calves

机译：一种随机对照临床试验，评价鼻内呼吸疫苗对荷斯坦乳制牛犊牛犊健康，超声肺固结和生长的影响

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Although passive transfer of antibodies to the newborn calf provides many great benefits, high levels of maternal antibodies may limit the ability of the calf to respond to parenterally administered vaccines against the respiratory viruses associatedwith bovine respiratory disease (BRD). Experimental challenge studies have demonstrated varying levels of efficacy of vaccines administered via the intranasal route. Unfortunately, direct identification of lung lesions associated with BRD requires euthanasia and often limits the size of study populations. As an alternative, thoracic ultrasonography (US) can be performed quickly and provides an accurate antemortem assessment of lung health. Therefore, the purpose of this randomized controlled clinical trial was to evaluate the effect of an intranasal vaccine on calf health, ultrasonographic lung lesions, and growth in young Holstein calves.
机译：虽然抗体对新生儿小牛的被动转移提供了许多巨大的益处，但高水平的母体抗体可能限制小牛对肠胃呼吸道疾病（BRD）相关的呼吸病毒响应肠胃外给药的能力。实验挑战研究表明，通过鼻内途径给药的疫苗有效的不同程度。不幸的是，直接鉴定与BRD相关的肺病变需要安乐死，并且通常限制研究人群的大小。作为替代方案，可以快速进行胸廓超声（US）并提供肺部健康的准确的抗恶化评估。因此，这种随机对照临床试验的目的是评估鼻内疫苗对小腿健康，超声肺病变和年轻荷斯坦小牛生长的影响。

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