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Targeted Costimulation with Novel Single-Chain 4-1BBL or OX40L Antibody-Fusion Proteins Promotes Tumor Directed T Cell Activation

机译：具有新型单链4-1BBL或OX40L抗体融合蛋白的靶向共刺激促进了肿瘤指导的T细胞活化

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Cytokine-mediated costimulation of T cells is an important aspect addressed by novel strategies of cancer immunotherapy. In order to circumvent potential side effects caused by systemic activation, we focus on tumor-directed antibody-cytokine fusion proteins, targeting the cytokine to the tumor site and presenting it there in a membrane bound form.

机译：细胞因子介导的T细胞的共刺激是通过癌症免疫疗法的新策略解决的一个重要方面。为了避免由全身激活引起的潜在副作用，我们专注于肿瘤定向抗体 - 细胞因子融合蛋白，靶向肿瘤部位并以膜结合形式呈现。

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《PEGS》|2015年||共1页
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Sina Fellermeier; Jan-Erik Meyer; Stefan Bader; Anastasiia Bondarieva; Ozlem Tiireci; Klaus Pfizenmaier; Rol Kontermann; Dafhe Muller;
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中图分类生物工程学（生物技术）;
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专利

1. 人乳腺癌OX40L转基因细胞株的构建及其对T细胞的共刺激作用 [J] . 施勤, 王勤, 陈永井, 癌症（英文版） . 2006,第002期
2. Influence of antigen density and immunosuppressive factors on tumor-targeted costimulation with antibody-fusion proteins and bispecific antibody-mediated T cell response [J] . Sapski Sabrina, Beha Nadine, Kontermann Roland E., Cancer immunology, immunotherapy : . 2020,第11期

机译：抗原密度和免疫抑制因子对抗体 - 融合蛋白和双特异性抗体介导的T细胞反应的影响对肿瘤靶向成果的影响
3. Single-chain Fv immunoliposomes for the targeting of fibroblast activation protein-expressing tumor stromal cells. [J] . Baum P, Muller D, Ruger R, Journal of drug targeting . 2007,第6期

机译：单链Fv免疫脂质体，用于靶向表达成纤维细胞活化蛋白的肿瘤基质细胞。
4. A KSHV microRNA Directly Targets G Protein-Coupled Receptor Kinase 2 to Promote the Migration and Invasion of Endothelial Cells by Inducing CXCR2 and Activating AKT Signaling [J] . Brian J. Krueger, Chun Lu, Cong Wang, PLoS Pathogens . 2015,第9期

机译：KSHV microRNA直接靶向G蛋白偶联的受体激酶2，通过诱导CXCR2和激活AKT信号来促进内皮细胞的迁移和侵袭。
5. Targeted Costimulation with Novel Single-Chain 4-1BBL or OX40L Antibody-Fusion Proteins Promotes Tumor Directed T Cell Activation [C] . Sina Fellermeier, Jan-Erik Meyer, Stefan Bader, PEGS . 2015

机译：具有新型单链4-1BBL或OX40L抗体融合蛋白的靶向共刺激促进了肿瘤指导的T细胞活化
6. Murine Lymphokine-activated Killer(LAK)Cells: Establishment of LAK Cell Clones,Analysis of Target Cell Killing Mechanism and Application for Tumor Therapy [D] . 加藤和則 1991

机译：小鼠淋巴因子激活的杀伤（LAK）细胞：LAK细胞克隆的建立，靶细胞杀伤机制的分析及其在肿瘤治疗中的应用
7. MiR-23a promotes TGF-β1-induced EMT and tumor metastasis in breast cancer cells by directly targeting CDH1 and activating Wnt/β-catenin signaling [O] . Fei Ma, Wenjie Li, Chunxiao Liu, 2017

机译：通过直接靶向CDH1和激活Wnt /β-catenin信号传导MiR-23a促进TGF-β1诱导的乳腺癌EMT和肿瘤转移
8. Targeting multidrug resistant tumor cells with a recombinant single-chain FV fragment directed to P-glycoprotein [O] . Revital Niv, Yehuda G. Assaraf, Dina Segal, 2001

机译：用针对p-糖蛋白的重组单链Fv片段靶向多药抗性肿瘤细胞
9. SV40 large tumor antigen and the tumor suppressor p53 are phosphorylated by a DNA-activated protein kinase from human cells. [R] . Lees-Miller, S. P., Chen, Y. R., Anderson, C. W. 1990

机译：sV40大肿瘤抗原和肿瘤抑制因子p53被来自人细胞的DNa活化蛋白激酶磷酸化。

Targeted Costimulation with Novel Single-Chain 4-1BBL or OX40L Antibody-Fusion Proteins Promotes Tumor Directed T Cell Activation

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