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首页> 外文会议>International Conference on Advancements of Medicine and Health Care through Technology >Preparation, Characterization and Preliminary Evaluation of Magnetic Nanoparticles based on Biotinylated N-palmitoyl Chitosan
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Preparation, Characterization and Preliminary Evaluation of Magnetic Nanoparticles based on Biotinylated N-palmitoyl Chitosan

机译：基于生物素化N-Palmitoyl壳聚糖的磁纳米粒子的制备，表征及初步评价

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Magnetic nanoparticles based on biotinylated N-palmitoyl chitosan and magnetite have been prepared via ionic gelation method. Dynamic light scattering results showed that magnetic nanoparticles average size is dependent on a series of parameters: polymer concentration, weight ratio polymer/cross-linking agent and the stirring speed. In vitro release studies have shown the ability of magnetic nanoparticles to release an antitumoral drug (Doxorubicin) for a period of 6 hours whereas in vitro cytotoxicity tests indicated that the prepared magnetic nanoparticles exhibited anti-proliferative effects on tumoral cells (MCF-7 cell line human breast adenocarcinoma), up to the lowest tested concentration. Fluorescence microscopy revealed that magnetic nanoparticles (BMN6-DOX) were internalized in MCF-7 cells. These properties indicate the potential application as targeted drug delivery system for breast cancer treatment.
机译：基于生物素化的N-棕榈酰壳聚糖和磁铁矿的磁性纳米颗粒已通过离子胶凝法制备。动态光散射结果表明，磁性纳米粒子的平均尺寸取决于一系列参数：聚合物浓度，重量比聚合物/交联剂和搅拌速度。体外释放研究表明，磁性纳米颗粒释放抗肿瘤药物（多柔比星）的能力为6小时，而在体外细胞毒性试验表明制备的磁性纳米粒子对肿瘤细胞表现出抗增殖作用（MCF-7细胞人乳腺腺癌），最低测试浓度。荧光显微镜显示显示磁性纳米颗粒（BMN6-DOX）在MCF-7细胞中内化。这些性质表明潜在应用作为乳腺癌治疗的靶向药物递送系统。

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