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首页> 外文会议>European Association of Psychosomatic Medicine., Annual Meeting. >Study on the Correlation between Psychological Disorders, Clinical and Biological Parameters and the Evolution of Patients with Philadelphia Negative Chronic Myeloproliferative Neoplasms
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Study on the Correlation between Psychological Disorders, Clinical and Biological Parameters and the Evolution of Patients with Philadelphia Negative Chronic Myeloproliferative Neoplasms

机译：心理障碍，临床和生物学参数与费城阴性慢性肌酚瘤肿瘤患者的相关性研究

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Introduction: It is known that patients with Philadelphia negative - chronic myeloproliferative neoplasms (PnCMN) are prone to develop psychological disorders. We plan to investigate their presence and possible correlations with clinical and biological parameters and evolution in our patients. Material and method: We studied all those 80 patients with PnCMN found in the records of the Hematology service of our hospital in 2013. We looked at their age, waist circumference, hemoleucogram, platelets parameters, triglyceridemia, cholesterolemia, blood pressure, thrombotic complications, and psychological disorders: anxiety, depression, psychasthenia. The results were statistically analyzed. Results: Psychological disorders were present at 32 of 80 patients (40%). They were more common in patients with essential thrombocythemia (ET) (43.9%), compared to those with primary myelofibrosis (PM) (36.3%) and polycythemia vera (PV) (35,6%). In the entire group, the mental disorders have been correlated directly with thrombotic accidents (r=0.282) and JAK2V617F mutation (r=0.288). In patients with ET mental disorders were correlated directly with tryglyceridemia (r=0.384) and thrombotic accidents (r=0.300). In those with PV they were directly correlated with age (r=0.300), diastolic blood pressure (r=0.300) and thrombotic accidents (r=0.305). In patients with the PM they were directly correlated with age (r=0.286), waist circumference (r=0.355), systolic (r=0.285) and diastolic (r=0.302) blood pressure and inversely with the number of platelets (r=-0.563) and the average platelets volume (r=-0.437). Conclusion: Psychological disorders are common in patients with PnCMN and correlated with the presence of JAK2V617F mutation (that favours thromboses), thrombotic accidents, and some thrombotic risk factors (in some subgroups of patients). The stress could be one of the factors that explain the mentioned correlation.
机译：简介：众所周知，患有费城阴性 - 慢性肌酚肌瘤（PNCMN）的患者易于发展心理障碍。我们计划调查它们的存在和可能的相关性与临床和生物参数和患者的演变。材料和方法：我们研究了2013年我们医院血液学服务的记录中发现的所有80名患者。我们看着他们的年龄，腰围，血肿图，血小板参数，三甘油血症，胆固醇血症，血压，血栓形成并发症，和心理疾病：焦虑，抑郁症，心理脑干。结果在统计学分析。结果：80例患者中的32名（40％）存在心理障碍。与原发性髓颤（PM）（36.3％）和多胆症Vera（PV）（35,6％）相比，它们更常见的血小板（ET）（Et）（Et）（Et）（43.9％）患者。在整个组中，精神障碍直接与血栓外伤（R = 0.282）和JAK2V617F突变相关（R = 0.288）。在患有ET精神障碍的患者中直接与试糖血症（R = 0.384）和血栓干扰（R = 0.300）相关联。在PV的那些中，它们与年龄（R = 0.300）直接相关，舒张压（R = 0.300）和血栓性事故（R = 0.305）。在PM患者中，它们与年龄（r = 0.286）直接相关，腰围（r = 0.355），收缩压（r = 0.285）和舒张（r = 0.302）血压，并与血小板的数量相反（r = -0.563）和平均血小板体积（R = -0.437）。结论：心理障碍在PNCMN患者中常见，与JAK2V617F突变的存在相关（伴有血栓形成），血栓干扰事故和一些血栓性危险因素（在某些患者的亚组中）。压力可能是解释上述相关性的因素之一。

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