Detection of P16 and APC gene methylation inperipheral blood with liver cancer patients

机译：用肝癌患者检测P16和APC基因甲基化透过血液

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Objective: To investigate the aberrant methylation of P16 and adenomatouspolyposis coli (APC) gene in peripheral blood with liver cancer patients andevaluate their clinical significance. Methods: P16 and APC gene aberrantmethylation in liver cancer tumours, pericarcinous tissues, and their correspondingperipheral blood were detected by using real-time quantitative polymerase chainreaction (Real-time PCR) in 86 hepatocellular carcinoma (HCC) patients. Results:The methylation rate of P16 and APC gene in liver cancer tumor tissues wassignificantly higher than that in pericarcinous tissues and their correspondingperipheral blood (p < 0.05). The coincidence rate of methylation of P16 and APCgene in cancer tumor tissues and peripheral blood was 65.4% and 43.3%,respectively. The P16 gene methylation rate of peripheral blood in HBsAg positivegroup was higher than that in HBsAg negative group (p < 0.05). Conclusion: Thedetection of P16 gene methylation in peripheral blood may be used as an index inearly diagnosis and surveillance for liver cancer patients.

机译：目的：探讨P16上的异常甲基化和外周血adenomatouspolyposis大肠杆菌（APC）基因与肝癌患者andevaluate临床意义。方法：P16和APC基因aberrantmethylation肝癌肿瘤，pericarcinous组织，他们的correspondingperipheral血液中由86肝细胞癌（HCC）患者采用实时荧光定量聚合酶链反应（实时PCR）检测。结果：在肝癌肿瘤组织中pericarcinous组织P16和APC基因的甲基化率比wassignificantly更高和其correspondingperipheral血（P <0.05）。在癌肿瘤组织P16和APCgene和外周血的甲基化的，符合率为65.4％和43.3％。的外周血中的HBsAg positivegroup的P16基因的甲基化率明显高于在HBsAg阴性组（p <0.05）。结论：外周血P16基因甲基化Thedetection可以被用作一个索引inearly诊断和监测对肝癌患者。

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《International Conference on Human Health and Medical Engineering.》|2014年||共10页
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Lianhua Cui; Yang Song; Zhexun Lian; Jinmei Piao; Chengcheng Li; Meng Liu; Fuguo Yang; Minho Shin; Hee Nam Kim;
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中图分类临床医学;
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Detection of P16 and APC gene methylation inperipheral blood with liver cancer patients

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