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首页> 外文会议>International Conference on Human Health and Medical Engineering. >The diversity of kdr allele mutation, and resistance detection in the voltage-gated sodium channel of Culex pipiens pallens from Shandong Province, China
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The diversity of kdr allele mutation, and resistance detection in the voltage-gated sodium channel of Culex pipiens pallens from Shandong Province, China

机译：中国山东省山东省Culex pipiens Pallens电压门控钠通道的kdr等位基因突变和抗性检测的多样性

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This study aims to investigate deltamethrin resistance in Culex pipiens pallens and its association with knockdown resistance (kdr) mutation as well as to explore the establishment of a mosquito-resistance testing method. Using specific primers through polymerase chain reaction (PCR), kdr gene sequences isolated from wild Cx. pipiens pallens mosquitoes were sequenced. Linear regression analysis was used to determine the relationship between the mutation and deltamethrin resistance. Two alternative fair-like mutations, L1014F and L1014S, were positively related to the deltamethrin-resistant phenotype. A novel mutation, Thymine Cytosine Thymine (TCT), was identified for the first time in the Voltage Gated Sodium Channels (VGSC) of Cx. pipiens pallens. Three fair-like mutations in Cx. pipiens pallens were positively related to the deltamethrin-resistant phenotype.
机译：本研究旨在调查Culex Pipiens Pallens的临甜菊抗性及其与敲低电阻（KDR）突变的关系以及探索蚊子电阻测试方法的建立。通过聚合酶链反应（PCR），从野生CX中分离的KDR基因序列使用特异性引物。 Pipiens Pallens蚊子被测序。线性回归分析用于确定突变与漂白素抗性之间的关系。两种替代的公平突变，L1014F和L1014S与含达氨酰胺抗性表型正相关。在CX的电压门控钠通道（VGSC）中首次鉴定了一种新的突变胸腺嘧啶胸腺氨酸胸腺嘧啶（TCT）。 Pipiens Pallens。 CX中的三个公平突变。 Pipiens Pallens与抗氨甲菊酯的表型正相关。

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