NANOBODIES FOR THE STRUCTURAL AND FUNCTIONAL INVESTIGATION OF GPCR TRANSMEMBRANE SIGNALING

机译：GPCR跨膜信号传导结构和功能调查的纳米级

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My view of the present state of research on GPCRs and transporters: ligands, cofactors, drug development Many membrane proteins including GPCRs and transporters are conformationally complex molecules. These are exiting times because we are starting to collect high resolution structures of the key functional conformers for a number of model systems. Most important, we are also witnessing the development of appropriate biophysical methods to study the(thermo)dynamics of the conformational transitions and the way ligands, cofactors, lipids or other proteins disturb these conformational equilibria. Ultimately, we will have to incorporate the contribution of the electrochemical membrane potentials to fully understand transmembrane transport and signaling. No doubt that the remarkable progress that we are making in these fields will lead to better drugs.

机译：我对目前的GPCR和运输机研究状态：配体，辅助actors，药物开发许多膜蛋白，包括GPCR和转运蛋白是构象复杂的分子。这些是退出的时间，因为我们开始为许多模型系统收集关键功能符合特器的高分辨率结构。最重要的是，我们还目睹了开发适当的生物物理方法，以研究构象过渡的（Thermo）动态和配体，辅助因子，脂质或其他蛋白质干扰这些构象平衡的方式。最终，我们必须纳入电化学膜电位的贡献来完全理解跨膜运输和信号传导。毫无疑问，我们在这些领域所做的显着进展将导致更好的药物。

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《International Solvay Conference on Chemistry, "New Chemistry and New Opportunities from the Expanding Protein Universe"》|2014年|xxiii 355 p. :|共3页
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ELS PARDON; JAN STEYAERT;
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中图分类 Q51-532;
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NANOBODIES; STRUCTURAL; FUNCTIONAL INVESTIGATION;

机译：纳米级;结构;功能调查;

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1. Structure-Based Sequence Alignment of the Transmembrane Domains of All Human GPCRs: Phylogenetic, Structural and Functional Implications [J] . Vaclav Cvicek, William A. Goddard III, Ravinder Abrol PLoS Computational Biology . 2016,第3期

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2. Functional importance of two conserved residues in intracellular loop 1 and transmembrane region 2 of Family A GPCRs: Insights from ligand binding and signal transduction responses of D-1 and D-5 dopaminergic receptor mutants [J] . Zhang Boyang, Yang Xiaodi, Tiberi Mario Cellular Signalling . 2015,第10期

机译：A系列GPCR的细胞内环1和跨膜区域2中两个保守残基的功能重要性：D-1和D-5多巴胺能受体突变体的配体结合和信号转导响应的见解
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4. NANOBODIES FOR THE STRUCTURAL AND FUNCTIONAL INVESTIGATION OF GPCR TRANSMEMBRANE SIGNALING [C] . ELS PARDON, JAN STEYAERT International Solvay Conference on Chemistry, "New Chemistry and New Opportunities from the Expanding Protein Universe" . 2014

机译：GPCR跨膜信号传导结构和功能调查的纳米级
5. Functional characterization of the interaction between G protein coupled receptors (GPCR) and regulators of G protein signaling (RGS) in yeast. [D] . Gaudio, Sabrina. 2006

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6. Structure-Based Sequence Alignment of the Transmembrane Domains of All Human GPCRs: Phylogenetic Structural and Functional Implications [O] . Vaclav Cvicek, William A. Goddard III, Ravinder Abrol 2016

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7. Identification of Key Structural Motifs Involved in 7 Transmembrane Signaling of Adhesion GPCRs [O] . Marta Arimont, Melanie van der Woude, Rob Leurs, 2019

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NANOBODIES FOR THE STRUCTURAL AND FUNCTIONAL INVESTIGATION OF GPCR TRANSMEMBRANE SIGNALING

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