• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>International Forum on Materials Analysis and Testing Technology(IFMATT) >Significance of Decoy Receptor 3 and IFN-γ/IL-4 in Peripheral Blood of Rheumatoid Arthritis Patient
【24h】

Significance of Decoy Receptor 3 and IFN-γ/IL-4 in Peripheral Blood of Rheumatoid Arthritis Patient

机译：诱饵受体3和IFN-γ/ IL-4在类风湿性关节炎患者外周血中的意义

获取原文
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

To investigate DcR3 Levels of peripheral blood in rheumatoid arthritis(RA), and analyzes the correlation between the DcR3 Levels of Peripheral Blood and the Disease Activity in Rheumatoid Arthritis Patient.The expression levels of DcR3 mRNA in peripheral Blood monocytes of 80 RA patients and 50 healthy controls were detected by real-time polymerase chain reaction, the levels of DcR3, IL-4 and IFN-γ in serum were detected by ELISA(enzyme-linked immuno sorbent assay). The expression levels of DcR3 mRNA of active stage in RA patients were higher than that of remission stage in RA patients and healthy controls(P<0.05); The levels of DcR3, IFN-γ and IFN-γ/IL-4 of active stage in RA patients were higher than that of remission stage in RA patients and healthy controls(P<0.01);;The correlationships between DcR3 mRNA levels, IFN-γ/IL-4 and active renal score (DAS28)show positive correlation.The expression levels of peripheral blood DcR3 does significant increase in RA active patients and it is closely related with the activity of the disease which suggesting that DcR3 migh involved in the pathological process.
机译：为了研究类风湿性关节炎（RA）中的DCR3水平，分析了类风湿性关节炎患者的DCR3水平与疾病活性之间的相关性。80ra患者外周血单核细胞中DCR3 mRNA的表达水平通过实时聚合酶链反应检测健康对照，通过ELISA检测血清中DCR3，IL-4和IFN-γ的水平（酶联免疫吸附剂测定）。 RA患者活性阶段DCR3 mRNA的表达水平高于RA患者和健康对照中的缓解阶段（P <0.05）; RA患者活性阶段的DCR3，IFN-γ和IFN-γ/ IL-4的水平高于RA患者和健康对照中的缓解阶段（P <0.01）;; DCR3 mRNA水平，IFN之间的相关性-γ/ IL-4和活性肾脏分数（DAS28）显示正相关。外周血DCR3的表达水平对RA活性患者的显着增加，它与疾病的活动密切相关，这表明DCR3 MIGH参与其中病理过程。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号