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Detection of RET Mutation in Thai Families with Multiple Endocrine Neoplasia 2A (MEN2A) by Real Time PCR Technique: Rajavithi Hospital

机译：用实时PCR技术检测泰国家庭中泰国家庭的RET突变：Rajavithi医院

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Multiple endocrine neoplasia type 2A (MEN 2A) is an inherited disease caused by mutations in the RET proto-oncogene, and is responsible for the development of endocrine neoplasia. The detection of RET mutation has important diagnosis and therapeutic impacts. The aim of this study was to detect RET mutation in Thai families with MEN2A by Real time PCR technique and to develop SYBR green with melting curve analysis for genotyping codon 634 mutations in the RET proto-oncogene in Thai family. We screened the RET gene in three families (22 patients) with MEN2A, living in the upper central region and north region of Thailand. DNA was obtained from blood samples of all patients. PCR amplification was performed using specific primers for exon11.

机译：多个内分泌瘤形成2A型（男性2A）是由RET原癌基因突变引起的遗传疾病，并负责内分泌瘤形成的发育。 RET突变的检测具有重要的诊断和治疗影响。本研究的目的是通过实时PCR技术检测泰国家庭的RET突变，并通过实时PCR技术进行SYBR Green，以泰国家族的RET原癌基因子突变进行熔化曲线分析。我们用Men2a筛选了三个家庭（22名患者）的RET基因，居住在泰国的中部地区和北部地区。 DNA是从所有患者的血液样本获得的。使用针孔11的特异性引物进行PCR扩增。

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《International Molecular Medicine Tri-Conference.》|2016年|1 CD-ROM ;|共1页
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Suchada Suphanpayak; Sathit Niramitmahapanya; Pornake Athipan;
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1. Generation of an induced pluripotent stem cell line from a patient with hereditary multiple endocrine neoplasia 2A (MEN2A) syndrome with RET mutation - ScienceDirect [J] . J. Hadoux, O. Féraud, F. Griscelli, Stem cell research . 2016,第1期

机译：患有RET突变的遗传性多发性内分泌肿瘤2A（MEN2A）综合征患者的诱导多能干细胞系的产生-ScienceDirect
2. A Family of Multiple Endocrine Neoplasia Type 2A (MEN 2A) with Cys630Tyr RET Germline Mutation: Report of a Case [J] . HIROYUKI YONEKAWA, IWAO SUGITANI, YOSHIHIDE FUJIMOTO, Endocrine journal . 2007,第4期

机译：Cys630Tyr RET生殖细胞突变的多发性内分泌肿瘤2A型（MEN 2A）家族：病例报告
3. A Family of Multiple Endocrine Neoplasia Type 2A (MEN 2A) with Cys630Tyr RET Germline Mutation: Report of a Case [J] . Hiroyuki YONEKAWA, Iwao SUGITANI, Masami ARAI, Endocrine journal . 2007,第4期

机译：Cys630Tyr RET生殖细胞突变的多发性内分泌肿瘤2A型（MEN 2A）家族：病例报告
4. Detection of RET Mutation in Thai Families with Multiple Endocrine Neoplasia 2A (MEN2A) by Real Time PCR Technique: Rajavithi Hospital [C] . Suchada Suphanpayak, Sathit Niramitmahapanya, Pornake Athipan International Molecular Medicine Tri-Conference. . 2016

机译：用实时PCR技术检测泰国家庭中泰国家庭的RET突变：Rajavithi医院
5. Activating mutations in thec-RET proto-oncogene causes Multiple Endocrine Neoplasia Type 2. [D] . Smith, Constance Leonie. 1999

机译：c-RET原癌基因中的激活突变导致2型多发性内分泌肿瘤。
6. RET codon 618 mutations in Saudi families with multiple endocrine neoplasia Type 2A and familial medullary thyroid carcinoma [O] . Faiza Qari 2013

机译：沙特家族多发性内分泌肿瘤2A型和家族性甲状腺髓样癌的RET密码子618突变
7. Generation of an induced pluripotent stem cell line from a patient with hereditary multiple endocrine neoplasia 2A (MEN2A) syndrome with RET mutation [O] . J. Hadoux, O. Féraud, F. Griscelli, 2016

机译：来自具有RET突变的遗传性多发性内分泌腺瘤2a（mEN2a）综合征患者的诱导多能干细胞系的产生

Detection of RET Mutation in Thai Families with Multiple Endocrine Neoplasia 2A (MEN2A) by Real Time PCR Technique: Rajavithi Hospital

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