• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>International Molecular Medicine Tri-Conference. >Cancer Associated Macrophage-Like (CAMLs) Cells in Circulation Predict Progression and Survival in All Stages of Solid Tumors
【24h】

Cancer Associated Macrophage-Like (CAMLs) Cells in Circulation Predict Progression and Survival in All Stages of Solid Tumors

机译：癌症相关的巨噬细胞样（CAML）细胞在循环中预测实体肿瘤的所有阶段的进展和生存

获取原文
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: We have previously demonstrated that cancer associated macrophage-like cells (CAMLs) are a cancer specific giant polyploid cell that circulates in the blood of patients with solid tumors. Building on our initial discovery, others have shown that these hyperploidy cells are an innate immune response that is associated with decreased survival. However to date, no study has been done to elucidate their clinical significance as in relation to the various stages of malignant disease. We established a 2 year prospective study of 315 patients from a variety of solid tumors (breast, prostate, lung, renal cell, pancreas, and esophageal) comparing the morphological properties of CAMLs in both early and late stage disease as they relate to progression free (PFS) and overall survival (OS). These data suggest that large CAML size has a significant negative correlation with PFS and OS in a variety of solid tumor regardless of stage, which indicates their broad use as a non-invasive blood based biomarker in solid tumors.
机译：背景：我们以前证明癌症相关的巨噬细胞样细胞（CAML）是癌症特异性巨型多倍体细胞，其在患有实体肿瘤患者的血液中循环。在我们的初始发现上建立，其他人表明，这些超宽度细胞是一种与生存率下降相关的先天免疫反应。然而，迄今为止，已经没有进行研究以阐明其与恶性疾病的各个阶段相关的临床意义。我们建立了2岁的前瞻性研究了315名来自各种实体肿瘤的患者（乳腺，前列腺，肺，肾细胞，胰腺和食道）比较了早期和晚期疾病的CAML的形态学特性，因为它们与进展有关（PFS）和总体生存（OS）。这些数据表明，无论阶段如何，大型CAML尺寸与各种实体肿瘤中的PFS和OS具有显着的负相关性，这表明其广泛用作实体瘤中的非侵入性血液的生物标志物。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号