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首页> 外文会议>National Fusarium Head Blight Forum Conference >RESISTANCE MECHANISMS AND MANAGEMENT OF GIBBERELLA ZEAE TO BENZIMIDAZOLE FUNGICIDE CARBENDAZIM AND ANOVEL FUNGICIDE PHENAMACRIL (JS399-19)
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RESISTANCE MECHANISMS AND MANAGEMENT OF GIBBERELLA ZEAE TO BENZIMIDAZOLE FUNGICIDE CARBENDAZIM AND ANOVEL FUNGICIDE PHENAMACRIL (JS399-19)

机译：Gibberella Zeae对苯并咪唑杀菌剂的抗性机制和管理碳氮唑和Anovel杀菌剂Phenamacril（JS399-19）

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In China, Gibberella zeae is the dominant pathogen causing wheat head blight. Carbendazim (MBC) has been widely used to control this disease since the 1970s. However, the resistance to MBC is currently serious in G. zeae. Though the MBC-resistance wascontrolled by one major gene and is involved in mitotic division, no mutation in the target beta-tubulin was found, which was different from other filamentous fungi. To identify the MBC-resistance mechanism of G. zeae, other tubulin genes were analyzed.Alterations at amino-acid codon 17 or 167 or 198 or 200 in beta2-tubulin were found to correspond to the different phenotypes of MBC-sensitivities. Deletion/complementation of the beta2-tubulin gene as well as mononucleotide displacement and affinity ofMBC binding tubulins validated the point mutations conferring resistance of G. zeae to MBC. It is interested to find that MBC-resistance mutation leads to increased expression of deoxynivalenol (DON) biosynthesis genes. Compared to the wild-type MBC-sensitive strain, the resistant strain produced twice as much DON in infected grains. Novel chemical, phenamacril (development code no. JS399-19) 2-cyano-3-amino-3-phenylancryic acetate is recommended as a Fusarium specific fungicide to control MBC-resistance Fusarium head blight.
机译：在中国，吉伯拉施肥是导致小麦头枯萎病的主要病原体。 Carbendazim（MBC）以来已被20世纪70年代以来被广泛用于控制这种疾病。然而，对MBC的抗性目前在G. Zeae中严重。虽然MBC抗性由一个主要基因进行了控制并且参与有丝分裂，但发现靶β-小蛋白的突变未发现，这与其他丝状真菌不同。为了鉴定G. Zeae的MBC抵抗机制，分析了其他微管蛋白基因。发现氨基酸密码子17或167或198或200的β2-微管蛋白的αα对应于MBC-敏感性的不同表型。 β2-微管蛋白基因的缺失/互补和MBC结合小管蛋白的单核苷酸位移和亲和力验证了G. Zeae对MBC的抵抗力的点突变。有兴趣发现MBC抗性突变导致脱氧苯酚（Don）生物合成基因的表达增加。与野生型MBC敏感菌株相比，耐药菌株两倍于受感染的颗粒。新型化学品，发育代码NO.JS399-19）2-氰基-3-氨基-3-苯基甘蔗，建议作为镰刀菌特异性杀菌剂，以控制MBC抗性镰刀菌枯萎病。

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