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首页> 外文会议>Conference of the American^College^of^Veterinary^Internal^Medicine >PREVALENCE OF GENETIC DISEASE VARIANTS IN 100,000 PUREBRED AND MIXED BREED DOGS
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PREVALENCE OF GENETIC DISEASE VARIANTS IN 100,000 PUREBRED AND MIXED BREED DOGS

机译：遗传疾病变异在100,000名纯种和混合品种犬的患病率

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The annotation of the canine genome and subsequent development of efficient genomic tools over the past ten years has greatly facilitated gene discoveries in many genetic conditions across purebred dogs. The list of known mutations that an individualdog can potentially be tested for has grown from tens to hundreds, which has important veterinary diagnostic and breeding implications. The rapid growth of the number of genetic tests available has fostered a conceptual change in DNA-based diagnostics, transforming the field from one-by-one single gene testing to more comprehensive screening based on gene panels. Panel testing in large numbers of dogs, of diverse breed background and representing different geographic populations, provides a unique viewto the epidemiology of risk variants and their relevance for veterinary care, breeding programs and animal welfare. In particular, panel tests provide a uniquely efficient platform for exploring the poorly understood risk variant prevalence in mixed breed dogs, which is particularly relevant given that roughly half of the dogs in US are mixed breeds.
机译：犬基因组，并在过去的十几年的高效基因组工具后续发展的注释跨纯种犬许多遗传条件，极大地促进了基因的发现。 ，一个individualdog有可能为已经从几十发展进行测试，以数百个已知突变的名单，其中有重要的兽医诊断和繁殖的影响。可用的基因测试的数量的快速增长已经培养在基于DNA的诊断的概念的变化，从一个接一个单基因检测转化领域基于基因面板更全面的筛选。大量的狗的品种多样的背景和代表不同地理种群的人造板试验，提供了一个独特的viewto风险的流行病学变种和他们的兽医护理，育种计划和动物福利的相关性。特别是，面板测试提供了探索的混种狗知之甚少的风险变异发生率，考虑到大约一半在美国的狗是混合品种，这是特别相关的一个独特的高效平台。

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