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Echinococcus multilocularis: An Emerging Zoonotic Disease

机译:echinococcus multilcularis:一种新兴的动物疾病

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Echinococcus multiloculoris is a zoonotic tapeworm that occurs in central Europe, much of northern, central and eastern Eurasia, and parts of North America1. Adult parasites reside within the small intestine of definitive hosts, which are primarily wild canids (e.g. foxes, coyotes, wolves). However, in some areas, domestic dogs, and to a lesser extent cats, may act as definitive hosts. Eggs shed in the feces of these species are morphologically indistinguishable from foen/o-type eggs and are immediately infective for intermediate hosts which include various species of wild rodents2. Subsequent to ingestion, a hexacanth embryo is released from the egg, travels to the liver via the hepatic portal circulation and develops into alveolar hydatid cysts1.This larval stage of the parasite is comprised of numerous small vesicles lined with a germinal epithelium from which multiple protoscolices develop, undergoes exogenous budding, and behaves like an invasive tumour1. The resultant disease, alveolar echinococcosis (AE), is associated with extensive damage to the liver and occasionally spread to other locations within the intermediate host. When an infected intermediate host is ingested by a definitive host the life cycle is completed; development to themature tapeworm takes approximately 4-5 weeks3. Lastly, ingestion of eggs by people may also result in AE, a potentially severe, fatal disease that is currently an emerging issue in parts of central Europe.
机译:echinococcus multiloculoris是一种在中欧,北部,中欧和东欧和欧亚东部的大部分地区以及北美地区的一个动物园绦虫。成人寄生虫位于最终宿主的小肠内,主要是野生CANID(例如狐狸,土狼,狼)。然而,在某些地区,家养犬和较小程度的猫,可以充当明确的宿主。这些物种的粪便中的鸡蛋来自Foen / O型卵形态上难以区分,并且立即对中间体感染,包括各种野生啮齿动物2。摄入后,从鸡蛋中释放六酰吡喃胚胎,通过肝门静脉循环向肝脏进行,并发展成肺泡囊状囊肿1。寄生虫的幼虫阶段由多个原子溶解的新小囊泡组成发展,经历外源性萌芽,并表现得像侵入性的肿瘤1。所得疾病,肺泡呼吸功能亢进(AE)与对肝脏的广泛损害有关,偶尔蔓延到中间宿主内的其他位置。当受感染的中间宿主被确定的宿主摄取时,完成生命周期;发展到基础绦虫大约需要4-5周3。最后,人们摄入鸡蛋可能也可能导致AE,这是一个潜在严重的致命疾病,目前是中欧地区的新兴问题。

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