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Synthesis and Performance of A Novel Penetration Enhancer

机译：新型渗透增强剂的合成与性能

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Preparation and percutaneous absorption of 2-methyl-2-perfluoro-2'-methyl-3'-oxoca-proyloxyl ethoxycarbonyl ethyl-methyldipolyethoxylsilicane (V) were investigated. V was synthesized from 2-perfluoro-2'-methyl-3'-oxocaproyloxylethyl methacrylate and methyldichlorosilicane by hydrosilication, then by alcoholysis with polyglycol, and was characterized by FTIR and MS. The penetration percentage of diclofenac sodium in different solutions of 2% 1-menthol, 0.5% V, 2% 1-menthol-0.5% V and 2% azone were respectively determined with improved Franz equipment and using rat skin as transderma barrier. The enhancement ratios were 3.11, 1.19, 5.46 and 6.21, respectively. V with 1-menthol could improve the trasdermal amount of diclofenac sodium, especially, but sole V express bad performance for it.
机译：研究了2-甲基-2-全氟-2'-甲基-3'-氧化氨基 - 普罗氧基乙氧基羰基乙基 - 甲基二聚乙氧基硅烷（V）的制备和经皮吸收。 v通过氢化从2-全氟-2'-甲基-3'-氧化丙酸酯和甲基二氯硅烷合成，然后通过用聚乙二醇醇解，其特征在于FTIR和MS。 用改善的FRANZ设备和使用大鼠皮肤作为透明器屏障，分别用改善的FRANZ设备测定不同溶液的双氯芬酸钠钠的渗透百分比分别测定。 增强比例分别为3.11,1.19,5.46和6.21。 v为1-menthol可以提高双氯芬酸钠的血红蛋白量，尤其是唯一的表达对其的不良表现。

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