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Effect of environment around the cytosine in photochemical C to U transition using reversible DNA photo-cross-linking in DNA strand

机译：使用可逆DNA光交联在DNA链中使用可逆DNA光交联的胞嘧啶周围的胞嘧啶周围的胞嘧啶对胞嘧啶的影响

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The DNA/RNA editing is a powerful tool for the treatment of genetic disease, so far chemical editing methods using bisulfate etc. have been reported. However, application to living organisms is difficult due to complication of experimental conditions and other factors. We had successfully demonstrated photochemical DNA/RNA editing using 3-cyanovinylcarbazole (CNVK) as ultrafast photo-cross-linker 1,2.

机译：DNA / RNA编辑是一种用于治疗遗传疾病的有力工具，因此已经报道了使用亚硫酸氢盐等的光学编辑方法。然而，由于实验条件和其他因素的复杂性，难以应用于生物体。我们已成功地证明了使用3-氰系乙氨基咔唑（CNVK）作为超快照相交联1,2的光化学DNA / RNA编辑。

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来源
《日本化学会春季年会講演予稿集》|2018年|1 CD-ROM|共1页
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作者
Nozomi Honda; Siddhant Sethi; Shigetaka Nakamura;
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原文格式 PDF
正文语种
中图分类石油化学工业;
关键词
Photo-cross-linking; deamination reaction;

机译：光交联;脱氨反应;

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专利

1. Photo-Cross-Linking of XPC−Rad23B to Cisplatin-Damaged DNA Reveals Contacts with Both Strands of the DNA Duplex and Spans the DNA Adduct [J] . Tracy M. Neher Nadejda I. Rechkunova Olga I. Lavrik and John J. Turchi Biochemistry . 2010,第4期

机译：XPC-Rad23B与顺铂损坏的DNA的光交叉连接揭示了与DNA双链体的两条链的接触并跨越了DNA加合物
2. Photo-cross-linking of XPC-Rad23B to cisplatin-damaged DNA reveals contacts with both strands of the DNA duplex and spans the DNA adduct [J] . Neher T.M., Rechkunova N.I., Lavrik O.I., Biochemistry . 2010,第4期

机译：XPC-Rad23B与顺铂损坏的DNA的光交联揭示了与DNA双链体的两条链的接触并跨越了DNA加合物
3. Effect of substitution of photo-cross-linker in photochemical cytosine to uracil transition in DNA [J] . Siddhant Sethi, Yasuharu Takashima, Shigetaka Nakamura, Bioorganic and Medicinal Chemistry Letters . 2017,第16期

机译：光化学胞嘧啶替代光化学胞嘧啶在DNA中尿嘧啶转变的影响
4. Effect of environment around the cytosine in photochemical C to U transition using reversible DNA photo-cross-linking in DNA strand [C] . Nozomi Honda, Siddhant Sethi, Shigetaka Nakamura 日本化学会春季年会講演予稿集 . 2018

机译：使用可逆DNA光交联在DNA链中使用可逆DNA光交联的胞嘧啶周围的胞嘧啶周围的胞嘧啶对胞嘧啶的影响
5. Studies on the Reversible Photo-regulation of Strand Displacement with Azobenzene-tethered DNA [D] . Cheng Bohao, 程博豪 2019

机译：偶氮苯束缚DNA可逆光调节链置换的研究
6. Study of Photochemical Cytosine to Uracil Transition via Ultrafast Photo-Cross-Linking Using Vinylcarbazole Derivatives in Duplex DNA [O] . Siddhant Sethi, Shigetaka Nakamura, Kenzo Fujimoto 2018

机译：通过双链DNA中的乙烯基咔唑衍生物通过超快光交联的光化学胞嘧啶向尿嘧啶转化的研究
7. Enhanced Performance of DNA Methylation Markers by Simultaneous Measurement of Sense and Antisense DNA Strands after Cytosine Conversion [O] . Sarah Ø Jensen, Nadia Øgaard, Hans Jørgen Nielsen, 2020

机译：通过同时测量胞嘧啶转化后的感测和反义DNA链的同时测量DNA甲基化标志物的增强性能

Effect of environment around the cytosine in photochemical C to U transition using reversible DNA photo-cross-linking in DNA strand

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