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Design, Synthesis and RNase H activity of Hemi-Gapmer Type Peptide Ribonucleic Acid (PRNA)-DNA chimeras for the RNase H mediated catalytic oligonucleotide therapeutics

机译：半介距型肽核糖核糖核酸（PRNA）-DNA嵌合催化寡核苷酸治疗剂的设计，合成和RNase H活性

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Oligonucleotide therapeutics has received much attention as a promising candidate for next generation molecular targeted drugs. Despite the very attractive features, there still remain a major issue; i.e., the expression of therapeutic effect on non-target normal cells, called off-target effects [1].

机译：寡核苷酸治疗剂已作为下一代分子靶向药物的有希望的候选者获得了很多关注。尽管功能非常有吸引力，但仍然存在一个主要问题;即，表达对非靶正常细胞的治疗作用，称为偏离目标效果[1]。

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来源
《日本化学会春季年会講演予稿集》|2018年|1 CD-ROM|共1页
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作者
Masahito Inagaki; Daisuke Unabara; Ryohei Uematsu;
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正文语种
中图分类石油化学工业;
关键词
Peptide Ribonucleic Acid (PRNA); Hemi-gapmer type chimeric PRNA-DNA; Ischemia-selective oligonucleotide therapeutics; RNase H mediated catalytic RNA cleavage; Antisense activity;

机译：肽核糖核酸（pRNA）;Hemi-Gapmer型嵌合PRNA-DNA;缺血选择性寡核苷酸治疗剂;RNase H介导的催化RNA裂解;反义活动;

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专利

1. Module Strategy for Peptide Ribonucleic Acid (PRNA)-DNA and PRNA-Peptide Nucleic Acid (PNA)-DNA Chimeras: Synthesis and Interaction of Chimeras with DNA and RNA [J] . Uematsu Ryohei, Inagaki Masahito, Asai Mitsuo, Chemistry Letters . 2016,第3期

机译：肽核糖核酸（PRNA）-DNA和PRNA-肽核酸（PNA）-DNA嵌合体的模块策略：嵌合体与DNA和RNA的合成和相互作用
2. Benzene-glycol nucleic acid (BGNA)–DNA chimeras: synthesis, binding properties, and ability to elicit human RNase H activity [J] . Nazuki Niwa, Saki Shimizu, Yusuke Maeda, RSC Advances . 2017,第41期

机译：苯乙二醇核酸（BGNA）–DNA嵌合体：合成，结合特性和引发人类RNase H活性的能力
3. Induction of RNase H Activity by Arabinose-Peptide Nucleic Acid Chimeras [J] . Benedicte M. Patureau, Robert H. E. Hudson, Masad J. Damha Bioconjugate Chemistry . 2007,第2期

机译：阿拉伯糖-肽核酸嵌合体对RNA酶H活性的诱导
4. Design, Synthesis and RNase H activity of Hemi-Gapmer Type Peptide Ribonucleic Acid (PRNA)-DNA chimeras for the RNase H mediated catalytic oligonucleotide therapeutics [C] . Masahito Inagaki, Daisuke Unabara, Ryohei Uematsu 日本化学会春季年会講演予稿集 . 2018

机译：半介距型肽核糖核糖核酸（PRNA）-DNA嵌合催化寡核苷酸治疗剂的设计，合成和RNase H活性
5. Induction of RNase H activity by arabinose-peptide nucleic acids. [D] . Patureau, Benedicte Marie. 2006

机译：阿拉伯糖-肽核酸诱导RNase H活性。
6. RNase P-mediated inhibition of cytomegalovirus protease expression and viral DNA encapsidation by oligonucleotide external guide sequences [O] . Walter Dunn, Phong Trang, Umair Khan, 2001

机译：RNase P介导的巨细胞病毒蛋白酶抑制寡核苷酸外部表达和病毒DNA衣壳化指导序列
7. Synthesis of Peptide Ribonucleic Acid (PRNA)-DNA Chimera and Interaction with DNA and RNA [O] . T. Wada, Y. Maeda, N. Sawa, 2007

机译：肽核糖核酸（PRNA）-DNA嵌合物的合成及与DNA和RNA的相互作用

Design, Synthesis and RNase H activity of Hemi-Gapmer Type Peptide Ribonucleic Acid (PRNA)-DNA chimeras for the RNase H mediated catalytic oligonucleotide therapeutics

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