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首页> 外文会议>International Scientific and Practical Conference on Digitization of Agriculture - Development Strategy >Influence of Anti-tuberculosis Drug KIM-M2 on Morphology of Lymph Nodes, Spleen, Liver and Lungs of Guinea Pigs Infected with M. bovis
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Influence of Anti-tuberculosis Drug KIM-M2 on Morphology of Lymph Nodes, Spleen, Liver and Lungs of Guinea Pigs Infected with M. bovis

机译：抗结核药物Kim-M2对肉豆菌豚鼠淋巴结，脾，肝肺形态的影响

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Conjugation of immunogenic fraction separated from microbial cells of BCG strain with stimulating component proved to be a promising direction in the creation of anti-tuberculosis drugs. One of such components is KIM-M2, a complex of thermostable soluble antigens extracted from microbial cells of BCG strain incubated with formalin and conjugated with polyvinyl pyrrolidone and polyethyleneglycol. To study the impact of KIM-M2 on the morphology of lymph nodes, spleen, lungs and liver of guinea pigs, the animals of group 1 (control, n = 5) were injected subcutaneously with a virulent culture of M. bovis strain 8 at a dose of 0.001 mg/ml. Animals of group 2 (n = 5 subjects) were injected subcutaneously with KIM-M2 at a dose of 0.5 mg/ml of protein, then 30 days later they were injected with a virulent culture of M. bovis strain 8, subcutaneously at a dose of 0.001 mg/ml. Animals of group 3 (n = 5 subjects) were injected subcutaneously with a virulent culture of M. bovis strain 8 at a dose of 0.001 mg/ml, 14 days later they were injected with KIM-M2 at a dose of 0.5 mg/ml of protein. Histomorphologic changes in animals of group 1 can be considered as morphological equivalent of immune suppression reaction. At the same time, the animals from group 2 and especially from experimental group 3 showed an increase of immunogenesis that can be proved by a profound proliferation of lymphocytes and macrophages.
机译：在BCG菌株的微生物细胞中分离的免疫原性馏分的缀合在刺激组分中被证明是在抗结核药物的产生中的有希望的方向。其中一种组分是Kim-M2，一种从与福尔马林孵育的BCG菌株的微生物细胞提取的热稳定抗原的复合物，并与聚乙烯吡咯烷酮和聚乙二醇缀合。为了研究Kim-M2对淋巴结的形态，脾脏，肺和豚鼠的肝脏，第1组（对照，N = 5）皮下注射M. BOVIS菌株8的毒性培养物剂量为0.001mg / ml。在0.5mg / ml蛋白的剂量以0.5mg / ml蛋白的剂量皮下注射第2种（n = 5个受试者），然后在30天后，将它们用肥胖的肉菌菌株8的毒性培养物进行皮下注射0.001 mg / ml。将3组（n = 5个受试者）皮下注射肉毒菌菌株8的毒性培养物，剂量为0.001mg / ml，14天以0.5mg / ml的剂量注射KIM-M2的剂量蛋白质。第1组动物的组织形态学变化可以被认为是免疫抑制反应的形态学当量。同时，来自第2组，特别是来自实验组3的动物显示出免疫原性的增加，可通过淋巴细胞和巨噬细胞的深刻增殖证明。

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