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首页> 外文会议>International conference and exhibition on Pharmaceutical Sciences and Technology >In Vitro Antibacterial Activity of Hydrogels Containing Tamarind Seed Husk Extracts against Propionibacterium acnes
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In Vitro Antibacterial Activity of Hydrogels Containing Tamarind Seed Husk Extracts against Propionibacterium acnes

机译：含有罗望子种子壳壳提取物的水凝胶的体外抗菌活性对抗丙酮

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Propionibacterium acnes (P. acnes) is one of skin bacteria that induce acne comedone formation. Previous studies reported that P. acnes was susceptible to alcoholic seed husk extract of Tamarindus indica L. (T. indica), no studies have been reported about the susceptibility of water extract from tamarind seed husk to P. acnes. Therefore, the objectives of this investigation were to explore the antibacterial activity of water and ethanolic seed husk extracts from T. indica (wTSH and eTSH) against P. acnes and to compare antibacterial activity of hydrogels containing wTSH and eTSH extracts against P. acnes. wTSH and eTSH extracts were reddish brown powder, and oligomeric proanthocyanidin was identified by UV-Vis spectroscopy and high performance liquid chromatography as the main ingredient in the extracts. wTSH and eTSH extracts showed the average of total phenolic compounds of 408.3±0.01 and 385.5±0.02 mg GAE/g and exhibited very strong free radical scavenging ability by DPPH assay with IC50 value of 19.6±0.2 μg/ml and 18.8±0.2 μg/ml, respectively. In addition, wTSH and eTSH extracts showed good activity against P. acnes. The minimum inhibitory concentration (MIC) of wTSH and eTSH extracts was 500 and 250 μg/ml, and the minimum bactericidal concentration (MBC) of both extracts was 500 ug/ml. In conclusion, the hydrogels which composed of 0.1% wTSH or eTSH extracts, 2% HPMC, 15% glycerin and 1% paraben concentrate, exhibited weak acid with pH 5±2, good physical stability, i.e. good spreadability with pseudoplastic flow, and also exhibited noticeable anti P. acnes activity in fluorescent resazurin assay after storage in the accelerated conditions for 3 months.
机译：丙酮痤疮丙酸杆菌（P. Acnes）是诱导痤疮组氨基形成的皮肤细菌之一。以往的研究报告说，痤疮丙酸群岛的含酒精种子壳壳提取物的Tamarindus Indica L.（T. indica），没有关于从罗望子种子果壳到P. Acnes的水提取物的敏感性。因此，本研究的目的是探讨来自痤疮丙酸杆菌的水和乙醇种子壳提取物的抗菌活性，并比较含有WTSH和ETSH提取物的水凝胶的抗菌活性对抗P. Acnes。 WTSH和ETSH提取物是REDDISH棕色粉末，通过UV-Vis光谱和高效液相色谱法鉴定了低聚原霉蛋白作为提取物中的主要成分。 WTSH和ETSH提取物显示出408.3±0.01和385.5±0.02mg GAE / g的总酚类化合物的平均值，并通过DPPH测定具有非常强烈的自由基清除能力，IC50值为19.6±0.2μg/ mL和18.8±0.2μg/分别。此外，WTSH和ETSH提取物对P. Acnes的良好活动显示出良好的活动。 WTSH和ETSH提取物的最小抑制浓度（MIC）为500且250μg/ ml，两种提取物的最小杀菌浓度（MBC）为500μg/ mL。总之，由0.1％WTSH或ETSH提取物组成的水凝胶，2％HPMC，15％甘油和1％羟烷浓缩物，具有pH5±2，良好的物理稳定性，即与假塑性流动的良好繁殖性，以及在加速条件下储存3个月后，在储存后在荧光转基质测定中表现出明显的抗P. Acnes活性。

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