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Synthesis and Characterization of Polyethylene Glycol Modified Chitosan

机译：聚乙二醇改性壳聚糖的合成与表征

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Chitosan (CS) is known for excellent biodegradability and low immunogenicity. However, its low water solubility has hampered CS biomedical application. In this study, we aimed to modify CS with polyethylene glycol (PEG) to improve water solubility and explored the possibility to use as a drug delivery vehicle. Degree of substitution of PEG on CS was varied, ranged from 16% to 78%. After dispersing in water, CS-PEG750 and CS-PEG5000 could spontaneously form small nanoaggreagtes (NGs) at low concentration, with critical aggregation concentration ranged from 32 ?g/mL to 112 ?g/mL. Upon encapsulation of curcumin, all NGs were slightly bigger in size. CS-PEG750 (1:40) NGs showed the highest entrapment efficiency at 59%, while CS-PEG5000 (1:40) and (1:60) NGs exhibited 36.9% and 36.5% entrapment efficiency, respectively. With few steps of modification, this modified CS copolymers reveal improved water solubility and decent entrapment efficiency. Thus this copolymer is a potential contender as a drug delivery vehicle.
机译：壳聚糖（Cs）以优异的生物降解性和低免疫原性称为。然而，其低水溶性阻碍了CS生物医学应用。在这项研究中，我们旨在用聚乙二醇（PEG）来改变CS，以改善水溶性，并探讨用作药物递送载体的可能性。 PEG取代度为CS的变化，范围为16％至78％。在分散水后，Cs-PEG750和CS-PEG5000可以在低浓度下自发地形成小纳米型（NGS），临界聚集浓度范围为32Ω·克/l至112×g / ml。在染色姜黄素后，所有NG的尺寸均略大。 CS-PEG750（1:40）NGS显示出最高的夹带效率为59％，而CS-PEG5000（1:40）和（1:40）和（1:60）分别表现出36.9％和36.5％的夹紧效率。随着改性的几个步骤，该改性的CS共聚物揭示了改善的水溶解度和体面的截留效率。因此，该共聚物是作为药物递送型载体的潜在患者。

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