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Modern Methods of Etiotropic Therapy and Preventive Measures in Dogs Suffering Dirofilariasis

机译：患有Dirofilariasis的狗的雌激素治疗和预防措施的现代方法

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The paper presents the core findings of a study aimed at therapeutic efficacy of domestic antiparasitics such as Inspector Total C and Helmimax on the basis of moxidectin used for etiotropic therapy and prevention of dirofilariasis in dogs. The dogs were infested by D. immitis and D. repens nematodes under natural conditions. The microfilariae were identified using blood smear technique, the concentration method (Yastrebov 2004) and the filtration through membrane filters Millipore (Ireland). An antigen of adult mature dirofilaria was detected using Immuno Run Antigen Detection Kit CANINE HEARTWORM produced by Biogal (Israel). There were selected 57 dogs of different breeds aged 1 to 14 years. They were spontaneously infested by dirofilariasis in natural conditions and three groups were formed. Dogs from Group I (n=21) placebo were used for negative control. Dogs from Group II (n=19) were given the drug Inspector Total C once at a dose of 2.5 mg/kg (spot on). Dogs from Group III (n=17) were given the drug Helmimax once at a dose of 0.25 mg/kg (per os). Before and after the introduction of preparations, the animals have gone through clinical and hemolarvoscopic examinations on the 3rd, 14th, 30th, 45th and 60th day. It was established that domestic antiparasitics Inspector Total C and Helmimax on the basis of moxidectin in the above mentioned doses result in 100% death of microfilariae on the 3rd day after treatment regardless of the intensity of infection and the type of helminth. When used in mono mode for the period of three months, it leads to complete elimination of imaginal forms. Anthelmintics do not cause side effects and are well tolerated by animals.
机译：本文提出了一项研究的核心调查结果，旨在在莫苏蛋白的基础上用于嗜昔菌素的检查员总C和Helmimax的治疗效果，用于嗜血育素和预防狗的Dirofilariasis。 D. Immitis和D.在自然条件下被D. Immitis和D.释放的狗。使用血液涂片技术，浓缩法（Yastrebov 2004）和通过膜过滤器Millipore（爱尔兰）的过滤来鉴定微植物。使用Biogal（以色列）产生的免疫润滑抗原检测试剂罐全虫检测成年成熟Dirofilaria的抗原。选择了57只不同品种的57只不同品种的狗。它们被自然条件下的Dirofilariasis自发地感染，并形成了三组。来自I组（n = 21）安慰剂的狗用于负面控制。来自II组（n = 19）的狗以2.5mg / kg（点ON）的剂量给药总C.来自III组（n = 17）的狗以0.25mg / kg（每OS）的剂量给药一次药物Helmimax。在制剂的引入之前和之后，动物已经通过临床和血管镜检查于第3,14，第30,45和60天。结果是，在上述剂量的基础上，国内抗疟疾检查员总共C和Helmimax在莫克替菌素的基础上导致治疗后第3天的Microfilaria患者导致100％死亡，而不管感染强度和蠕虫的类型。当在三个月的单声道模式下使用时，它导致完全消除了想象形式。 Anthelmintics不会造成副作用，并被动物妥善耐受。

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