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Synthesis and Vitamin D Receptor Affinity of 16-Oxa Vitamin D3Derivatives-1

机译：16-OXA维生素D3远序列-1的合成和维生素D受体亲和力-1

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Novel 16-oxa vitamin D3 derivatives (A) were synthesized and their Vitamin Drecepeor (VDR) binding affinities were evaluated.1 The synthesis was accomplishedby a coupling reaction of the 16-oxa C,D-ring units 6,7 and A-ring units.RequiredA-ring units have been prepared by the procedure reported by us.

机译：合成了新的16-氧会维生素D3衍生物（A），并评估其维生素Drecepeor（VDR）结合亲和力.1，合成是通过16-氧气的C，D形环单元6,7和环的偶联反应完成的United.Requireda-Ring单位已通过我们报告的程序编制。

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《日本化学会春季年会》|2020年|1 CD-ROM|共1页
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Ogami Mayu; Ibe Kouta; Yamada Takeshi;
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中图分类石油化学工业;
关键词
16-oxa Vitamin D3; 16-oxa C; D-ring unit; A-ring unit; Vitamin D receptor(VDR) binding affinity;

机译：16-牛维生素D3;16-牛扣;D形圈单元;一个环单元;维生素D受体（VDR）结合亲和力;

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1. Synthesis and vitamin D receptor affinity of 16-oxa vitamin D_3 analogues [J] . Ibe Kouta, Yamada Takeshi, Okamoto Sentaro Organic & biomolecular chemistry . 2019,第48期

机译：16-氧杂维生素D_3类似物的合成及其对维生素D受体的亲和力
2. Identification of the subdomain in the nuclear receptor for the hormonal form of vitamin D-3, 1 alpha,25-dihydroxyvitamin D-3, vitamin D receptor, that is covalently modified by an affinity labeling reagent [J] . Swamy N, Kounine M, Ray R, Archives of Biochemistry and Biophysics . 1997,第1期

机译：通过亲和标记试剂共价修饰的维生素D-3、1α，25-二羟基维生素D-3，维生素D激素的激素形式在核受体中的亚结构域的鉴定
3. Probing the vitamin D sterol-binding pocket of human vitamin D-binding protein with bromoacetate affinity labeling reagents containing the affinity probe at C-3, C-6, C-11, and C-19 positions of parent vitamin D sterols [J] . Swamy N., Vskokovic MR., Ray R., Archives of Biochemistry and Biophysics . 2000,第2期

机译：用溴乙酸亲和标记试剂探测人维生素D结合蛋白的维生素D固醇结合口袋，该试剂在母体维生素D甾醇的C-3，C-6，C-11和C-19位置处含有亲和探针
4. Synthesis and Vitamin D Receptor Affinity of 16-Oxa Vitamin D3Derivatives-1 [C] . Ogami Mayu, Ibe Kouta, Yamada Takeshi 日本化学会春季年会 . 2020

机译：16-OXA维生素D3远序列-1的合成和维生素D受体亲和力-1
5. Role of vitamin D receptor and vitamin D binding protein restriction fragment length polymorphisms in determining dose response to vitamin D: A randomized double blind placebo controlled trial [D] . Sai, Adarsh. 2011

机译：维生素D受体和维生素D结合蛋白限制性片段长度多态性在确定对维生素D的剂量反应中的作用：一项随机双盲安慰剂对照试验
6. Hereditary vitamin D resistant rickets caused by a novel mutation in the vitamin D receptor that results in decreased affinity for hormone and cellular hyporesponsiveness. [O] . P J Malloy, T R Eccleshall, C Gross, 1997

机译：由维生素D受体的新突变引起的遗传性维生素D抗性rick病导致对激素和细胞低反应性的亲和力下降。
7. Six practical diets were formulated to contain 2.6 (the basal diet), 48.9, 95.5, 189.83, 382.4, 779.53 mg/kg vitamin C diet. After 8 weeks of feeding, growth performance, antioxidant status, and innate immunity of juvenile pufferfish were analyzed. Results showed that specific growth rate and protein efficiency ratio in fish fed diets supplemented with vitamin C were significantly higher than in fish fed the control diet. Dietary vitamin C significantly up-regulated the expression levels of growth hormone receptors and Insulin-like growth factor. Blood cell numbers and respiratory burst activity were enhanced in fish fed vitamin C diet. Serum alkaline phosphatase, glutamic-pyruvic transaminase, and glutamic-oxaloacetic transaminase activity were significantly influenced by the dietary vitamin C levels. Fish fed diets supplemented with vitamin C showed increased hepatic superoxide dismutase, glutathione peroxidase, and catalase activity, but decreased malondialdehyde activity. In addition, we found that dietary vitamin C can significantly up-regulate the expression levels of immune-related genes (HSP70, HSP90, BAFF, TNF-α and IL-6) in liver. These results indicate that dietary vitamin C can significantly influence growth performance, antioxidant status, and innate immunity of pufferfish. [O] . Cheng C-H, Liang H-Y., Guo Z-X., 2017

机译：配制了六种实用饮食，分别含有2.6（基础饮食），48.9、95.5、189.83、382.4、779.53 mg / kg维生素C饮食。喂食8周后，分析了幼崽河豚的生长性能，抗氧化剂状态和先天免疫力。结果表明，补充维生素C的鱼饲料的比生长速率和蛋白质效率比显着高于对照组的鱼。饮食中的维生素C显着上调了生长激素受体和胰岛素样生长因子的表达水平。喂鱼的维生素C饮食可提高血细胞数量和呼吸爆发活性。饮食中的维生素C水平显着影响血清碱性磷酸酶，谷氨酸-丙酮酸转氨酶和谷氨酸-草酰乙酸转氨酶的活性。补充维生素C的鱼饲料日粮中肝超氧化物歧化酶，谷胱甘肽过氧化物酶和过氧化氢酶活性增加，但丙二醛活性降低。此外，我们发现饮食中的维生素C可以显着上调肝脏中免疫相关基因（HSP70，HSP90，BAFF，TNF-α和IL-6）的表达水平。这些结果表明，饮食中的维生素C可以显着影响河豚的生长性能，抗氧化状态和先天免疫力。
8. Vitamin D3 Analogues with Low Vitamin D Receptor Binding Affinity RegulateChondrocyte Proliferation, Proteoglycan Synthesis, and Protein Kinase C Activity [R] . Greising, D. M. 1997

机译：具有低维生素D受体结合亲和力的维生素D3类似物调节软骨细胞增殖，蛋白多糖合成和蛋白激酶C活性

Synthesis and Vitamin D Receptor Affinity of 16-Oxa Vitamin D3Derivatives-1

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