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Effect of Sodium Alginate on the Non-specific Immune system of Carp, Cyprinus carpio

机译：海藻酸钠对鲤鱼鲤非特异性免疫系统的影响

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摘要

Carp which received intraperitioneal injection of sodium alginate showed high survival rate after challenge with E. tarda. In order to elucidate the immunoen-hancement by sodium alginate, we investigated its effects on the non-specific immune system of caro. Sodium alginate gave little effect in vivo and in vitro on the alternative complement pathway of carp. Intraperitoneal injection of alginate (2 g/100 g body wieght) did not affect the phagocytic activity of head kidney phagocyts (HKP), but greatly enhanced the migration of phagocytes to the peritoneal cavity. The number of induced cells was 16 to 50 times greaer than other kleukocyte-inducing substances (casein sodium, glycogen, liquid paraffin. polypeptone-soluble starch (1:1)and sodium thioglycollate) when injected at the same dose. In chemotaxis assays, migration of normal HKP to the culture supernatant of peritoneal exudate cells (PEC) increased when PEC were cultured with alginate, and migration of HKP obtained from alginate-injeted fish was significantly higher than that of normal HKP. These results indicate that sodium alginate stimulated PEC to produce chemotactic factor and concurrently enhanced chemotactic activity of HKP.
机译：接受腹膜内注射海藻酸钠的鲤鱼在用大肠杆菌感染后表现出较高的成活率。为了阐明藻酸钠的免疫增强作用，我们研究了其对胡萝卜非特异性免疫系统的影响。海藻酸钠在体内和体外对鲤鱼的补体途径几乎没有影响。腹膜内注射藻酸盐（2 g / 100 g体重）不影响头肾吞噬细胞（HKP）的吞噬活性，但大大增强了吞噬细胞向腹膜腔的迁移。当以相同剂量注射时，诱导细胞的数量比其他诱导白细胞的物质（酪蛋白钠，糖原，液体石蜡，聚pe可溶淀粉（1：1）和巯基乙酸钠）多16至50倍。在趋化性测定中，用藻酸盐培养PEC时，正常HKP向腹膜渗出液（PEC）培养上清的迁移增加，并且从藻酸盐注射鱼中获得的HKP迁移显着高于正常HKP。这些结果表明海藻酸钠刺激PEC产生趋化因子并同时增强HKP的趋化活性。

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  • 来源
    《》|1995年|p.246-250|共5页
  • 会议地点 Beijing(CN);Beijing(CN)
  • 作者

    K. Fujiki; T. Yano;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 水产、渔业;
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