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Effect of Sodium Alginate on the Non-specific Immune system of Carp, Cyprinus carpio

机译：海藻酸钠对鲤鱼，鲤鱼鲤鱼非特异性免疫系统的影响

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Carp which received intraperitioneal injection of sodium alginate showed high survival rate after challenge with E. tarda. In order to elucidate the immunoen-hancement by sodium alginate, we investigated its effects on the non-specific immune system of caro. Sodium alginate gave little effect in vivo and in vitro on the alternative complement pathway of carp. Intraperitoneal injection of alginate (2 g/100 g body wieght) did not affect the phagocytic activity of head kidney phagocyts (HKP), but greatly enhanced the migration of phagocytes to the peritoneal cavity. The number of induced cells was 16 to 50 times greaer than other kleukocyte-inducing substances (casein sodium, glycogen, liquid paraffin. polypeptone-soluble starch (1:1)and sodium thioglycollate) when injected at the same dose. In chemotaxis assays, migration of normal HKP to the culture supernatant of peritoneal exudate cells (PEC) increased when PEC were cultured with alginate, and migration of HKP obtained from alginate-injeted fish was significantly higher than that of normal HKP. These results indicate that sodium alginate stimulated PEC to produce chemotactic factor and concurrently enhanced chemotactic activity of HKP.
机译：接受藻类酸钠尿酸钠注射的鲤鱼在挑战后患有E. Tarda攻击后的高存活率。为了阐明藻酸钠的免疫患者，我们研究了对Caro非特异性免疫系统的影响。海藻酸钠在鲤鱼的替代补体途径上对体内和体外效果不大。腹膜内注射海藻酸盐（2g / 100g体温）不影响头部肾吞噬细胞（HKP）的吞噬活性，但大大增强了吞噬细胞对腹膜腔的迁移。诱导细胞的数量比其他Kleukocyte诱导物质（酪蛋白钠，糖原，液体石蜡）的数量为16至50倍。当以相同剂量注入时，多肽可溶的淀粉（1：1）和硫代糖醇）。在趋化性测定中，当PEC用藻酸盐培养培养的腹膜渗出蛋白细胞（PEC）迁移到腹膜渗出物细胞（PEC）的培养上清液，并且从藻酸盐损伤的鱼中获得的HKP迁移显着高于正常HKP。这些结果表明，海藻酸钠刺激了PEC，以产生趋化因子并同时增强HKP的趋化活性。

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