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COMMON FEATURES OF THE QUORUM SENSING SYSTEMS IN VIBRIO SPECIES

机译：弧菌物种群体感应系统的共同特征

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摘要

In V. harveyi, the model for the regulation of luminescence includes sensors 1 and 2, LuxN and LuxQ, that autophosphorylate within the sensor recognition kinase domain, then transphosphorylate to the downstream receiver domain. Phosphorelay to the hpt (histidine-containing phosphate transfer) domain in LuxU followed by transfer to the response domain of the regulator, LuxO, then ensues. LuxO is a σ~(54)-binding activator whose phosphorylated form at low cell densities represses luminescence. As autoinducers (AI) accumulate, AI-1 interacts with LuxN, and AI-2, the luxS product, associates with a periplasmic protein LuxP to interact with LuxQ. The sensors switch from kinase to phosphatase activity causing inactivation of LuxO. With the recent discovery that luxS is present in many bacteria and appears to have similar interspecies functions, it is of interest to see whether the signal transduction pathway to LuxO is also widely distributed.
机译：在哈氏弧菌中，用于调节发光的模型包括传感器1和2，LuxN和LuxQ，它们在传感器识别激酶结构域内自磷酸化，然后再磷酸化至下游受体结构域。继而转移到LuxU中的hpt（含组氨酸的磷酸转移）结构域，然后转移至调节剂LuxO的响应结构域。 LuxO是一种σ〜（54）结合活化剂，其在低细胞密度下的磷酸化形式抑制了发光。随着自动诱导剂（AI）的积累，AI-1与LuxN相互作用，而luxS产物AI-2与周质蛋白LuxP缔合，从而与LuxQ相互作用。传感器从激酶活性转变为磷酸酶活性，导致LuxO失活。随着最近发现luxS存在于许多细菌中并且似乎具有相似的种间功能，最近的一个有趣的发现是通往LuxO的信号转导途径是否也广泛分布。

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