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首页> 外文会议>Conference on Biomedical Applications in Molecular, Structural, and Functional Imaging >Quantitative analysis of structural variations in corpus callosum in adults with Multiple System Atrophy (MSA)
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Quantitative analysis of structural variations in corpus callosum in adults with Multiple System Atrophy (MSA)

机译：多种系统萎缩（MSA）中成人胼um的结构变异的定量分析

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Multiple system atrophy (MSA) is a rare, non-curable, progressive neurodegenerative disorder that affects nervous system and movement, poses a considerable diagnostic challenge to medical researchers. Corpus callosum (CC) being the largest white matter structure in brain, enabling inter-hemispheric communication, quantification of callosal atrophy may provide vital information at the earliest possible stages. The main objective is to identify the differences in CC structure for this disease, based on quantitative analysis on the pattern of callosal atrophy. We report results of quantification of structural changes in regional anatomical thickness, area and length of CC between patient-groups with MSA with respect to healthy controls. The method utilizes isolating and parcellating the mid-sagittal CC into 100 segments along the length - measuring the width of each segment. It also measures areas within geometrically defined five callosal compartments of the well-known Witelson, and Hofer-Frahma schemes. For quantification, statistical tests are performed on these different callosal measurements. From the statistical analysis, it is concluded that compared to healthy controls, width is reduced drastically throughout CC for MSA group and as well as changes in area and length are also significant for MSA. The study is further extended to check if any significant difference in thickness is found between the two variations of MSA, Parkinsonian MSA and Cerebellar MSA group, using the same methodology. However area and length of this two sub-MSA group, no substantial difference is obtained. The study is performed on twenty subjects for each control and MSA group, who had T1-weighted MRI.
机译：多种系统萎缩（MSA）是一种罕见的不可治疗的渐进神经退行性疾病，影响神经系统和运动，对医学研究人员带来了相当大的诊断挑战。胼calloSum（cc）是大脑中最大的白质结构，使半球间通信，调用萎缩的量化可以在尽可能旧的阶段提供重要信息。主要目的是根据对胼enrophy模式的定量分析确定该疾病的CC结构的差异。我们向MSA与MSA相对于健康对照，向患者组之间的区域解剖厚度，区域和长度的定量结果报告结构变化的结构变化的结果。该方法利用隔离和将中矢状CC分离为100个段的长度 - 测量每个段的宽度。它还测量众所周知的Witelson和Hofer-Frahma计划的几何定义五个调用隔间内的区域。为了定量，对这些不同调用测量进行统计测试。从统计分析中，与健康对照相比，与健康对照相比，在MSA组的CC整个CC中宽度降低，以及面积和长度的变化对于MSA也很重要。进一步扩展了该研究以检查使用相同方法的MSA，Parkinsonian MSA和小脑MSA组的两个变化之间是否发现了任何显着差异。然而，这两个子MSA组的面积和长度，没有获得大量差异。该研究是对具有T1加权MRI的每种对照和MSA组的20个受试者进行。

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