• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>Conference on Biomedical Applications in Molecular, Structural, and Functional Imaging >Subject-specific Left Ventricular Dysfunction Modeling using Composite Material Mechanics Approach
【24h】

Subject-specific Left Ventricular Dysfunction Modeling using Composite Material Mechanics Approach

机译：采用复合材料力学方法进行课程特异性左心室功能障碍建模

获取原文
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Diverse cardiac conditions such as myocardial infarction and hypertension can lead to diastolic dysfunction as a prevalent cardiac condition. Diastolic dysfunctions can be diagnosed through different adverse mechanisms such as abnormal left ventricle (LV) relaxation, filling, and diastolic stiffness. This paper is geared towards evaluating diastolic stiffness and measuring the LV blood pressure non-invasively. Diastolic stiffness is an important parameter which can be exploited for more accurate diagnosis of diastolic dysfunction. For this purpose, a finite element (FE) LV mechanical model, which works based on a novel composite material model of the cardiac tissue, was utilized. Here, this model was tested for inversion-based applications where it was applied for estimating the cardiac tissue passive stiffness mechanical properties as well as diastolic LV blood pressure. To this end, the model was applied to simulate diastolic inflation of the human LV. The start-diastolic LV geometry was obtained from MR image data segmentation of a healthy human volunteer. The obtained LV geometry was discretized into a FE mesh before FE simulation was conducted. The LV tissue stiffness and diastolic LV blood pressure were adjusted through optimization to achieve the best match between the calculated LV geometry and the one obtained from imaging data. The performance of the LV mechanical simulations using the optimal values of tissue stiffness and blood pressure was validated by comparing the geometrical parameters of the dilated LV model as well as the stress and strain distributions through the LV model with available measurements reported on the LV dilation.
机译：多样性的心脏病（如心肌梗死和高血压）可以导致舒张功能障碍作为普遍存在的心脏病。通过不同的不良机制，舒张功能障碍可以诊断出诸如左心室（LV）松弛，填充和舒张刚度等不同的不利机制。本文旨在评估舒张性刚度并非侵入性地测量LV血压。舒张刚度是一种重要参数，可以利用更准确地诊断舒张功能障碍。为此目的，利用基于心脏组织新型复合材料模型的有限元（Fe）LV机械模型。这里，测试该模型用于基于反转的应用，其中施加用于估计心脏组织被动刚度机械性能以及舒张性LV血压。为此，应用模型以模拟人LV的舒张膨胀。从健康人志愿者的MR图像数据分割获得开始 - 舒张型LV几何。在进行Fe模拟之前，所获得的LV几何形状被离散到Fe网状物中。通过优化调整LV组织刚度和舒张型LV血压，以实现计算的LV几何形状与从成像数据获得的最佳匹配。通过比较扩张的LV模型的几何参数以及通过LV模型进行LV模型的LV模型来验证使用组织刚度和血压的最优值的LV机械模拟的性能。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号