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首页> 外文会议>Conference on reporters, markers, dyes, nanoparticles, and molecular probes for biomedical applications >Design and Development of Multifunctional Contrast Agents for Photoacoustic Imaging
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Design and Development of Multifunctional Contrast Agents for Photoacoustic Imaging

机译：光声成像多功能造影剂的设计与开发

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摘要

We have developed a multifunctional nanoagent, termed the combined imaging and therapy nanocage system (CIT-NS). This nanosystem platform consists of a poly(lactic-co-glycolic) acid polymer core and outer silver cage network. The inner core of CIT-NS is capable of carrying drugs, such as the chemotherapeutic agent doxorubicin, or imaging contrast agents, such as dyes or fluorescent compounds. The outer silver cage is specifically designed to enhance contrast in photoacoustic imaging, i.e., acoustic imaging of optical absorption. In this paper, methods to create the CIT-NS are described. Initial characterization indicates that the developed CIT-NS will significantly increase contrast in photoacoustic imaging while retaining the potential to deliver large payloads of drug simultaneously. Therefore, the CITNS may enable multi-modal imaging approaches or simultaneous imaging and therapy strategies to improve treatment and detection of cancer and other pathologies.
机译：我们开发了一种多功能的纳戈，称为组合的成像和治疗纳米证系统（Cit-NS）。该纳米系统平台包括聚（乳酸共甘油）酸聚合物芯和外银笼网络。 Cit-NS的内核能够携带药物，例如化学治疗剂多柔比星，或成像造影剂，例如染料或荧光化合物。外层银笼专门设计用于增强光声成像中的对比度，即光学吸收的声学成像。在本文中，描述了创建Cit-NS的方法。初始表征表明，发达的CIT-NS将显着增加光声成像中的对比度，同时保持潜力同时提供大量药物的有效载荷。因此，CIT可以使多模态成像方法或同时成像和治疗策略能够改善癌症和其他病理的治疗和检测。

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