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首页> 外文会议>International Conference on Biomedical Engineering and Informatics >Prevalence and charaterization of carbapenem-resistant Pseudomonas aeruginosa carrying metallo-#x03B2;-lactamases at different wards
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Prevalence and charaterization of carbapenem-resistant Pseudomonas aeruginosa carrying metallo-#x03B2;-lactamases at different wards

机译：不同病房携带金属-β-内酰胺蛋白铜绿假单胞菌铜绿假单胞菌的患病率与表征

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This study was conducted to investigate the molecular occurrence and dissemination of Pseudomonas aeruginosa producing MBLs recovered from the different wards in the affiliated hospital, Jilin. Antibiotic susceptibility test was determined using standard agar diffusion in conjunction with MBL screening methods. Plasmid profiles and pulsed-field gel electrophoresis were used to study the relatedness of isolates. The total of 120 were isolated from three wards and 89 strains (74.8%) produced MBLs, the number of 31 strains (25.2%) didn't produce MBLs. All MBLs isolates showed identical antimicrobial susceptibility profiles. Among P. aeruginosa producing MBLs, 79 strains (88.9%) were positive for blaVIM-2 gene, 12 strains (11.1%) contained blaIMP-3 gene, which were located on transferable plasmids with class 1 integron. All MBLs isolates were closely related by PFGE and plasmid analysis. This study confirmed the potential risk of dissemination of carbapenem-resistant Pseudomonas aeruginosa with inter-and intrahospital clonal transfer of patients.
机译：进行该研究以研究吉​​林附属医院不同病房的铜绿假单胞菌铜绿假单胞菌的分子发生和传播。使用标准琼脂扩散与MBL筛选方法结合测定抗生素敏感性试验。质粒曲线和脉冲场凝胶电泳用于研究分离物的相关性。从三个病房中分离了120个，89个菌株（74.8％）产生的MBL，31个菌株（25.2％）没有产生MBL。所有MBLS分离物显示出相同的抗微生物易感性谱。在P.铜绿假单胞菌中，产生MBL，79株（88.9％）为BLA Vim-2 基因，12株（11.1％）含有BLA IMP-3 基因，其位于可转移的质粒上，含有1级整合子。所有MBLS分离物与PFGE和质粒分析密切相关。本研究证实，耐肠道抗性铜绿假单胞菌的潜在风险与患者的间际颈部转移。

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