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Applications of Phase Type Survival Trees in HIV Disease Progression Modelling

机译:相型存活树木在艾滋病毒疾病进展模型中的应用

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It is important to model progression of a disease to understanding if the patient's condition is improving or getting worse. In the case of HIV disease, the change in the patient's CD4+ T cell count is used to calculate the progression of HIV disease i.e. if the CD4 count goes down it represent the progression of the patient's HIV disease. Due to the lack of an effective cure for HIV disease, it is crucial to monitor the disease progression to managing HIV disease effectively. Therefore, this study is aimed to model HIV disease progression by using phase type survival trees to cluster patients into homogenous groups based on their disease progression to understand the effect of different factors of prognostic significance and their interactions affecting the disease progression. The proposed methods are evaluated using an empirical data of 1,838 HIV-infected patients. The methods developed in this study can also be used for modelling the progression of other chronic conditions or diseases.
机译:如果患者的病症改善或变得更糟,可以对疾病的进展模拟疾病的进展是重要的。在艾滋病毒疾病的情况下,患者CD4 + T细胞计数的变化用于计算HIV疾病的进展,即,如果CD4计数下降,则表示患者艾滋病毒疾病的进展。由于缺乏对艾滋病毒疾病的有效治愈,有效地监测疾病进展至关重要。因此,本研究旨在通过使用相型存活树来模拟艾滋病毒疾病进展,以基于其疾病进展,以了解均质群体,了解不同因素对影响疾病进展的不同因素的影响。使用1,838名艾滋病毒感染患者的经验数据来评估所提出的方法。本研究开发的方法也可用于建模其他慢性病症或疾病的进展。

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