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首页> 外文会议>International Conference on Modelling, Monitoring and Management of Air Pollution >Impact of air pollution on pregnancy duration, birth outcomes and children's health: Polish Mother and Child Cohort
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Impact of air pollution on pregnancy duration, birth outcomes and children's health: Polish Mother and Child Cohort

机译：空气污染对妊娠期持续时间，出生结果和儿童健康的影响：波兰母亲和儿童队列

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The aim of this study was to evaluate the association between exposure to ambient air pollution and pregnancy duration, birth outcomes and children's health. The study was based on the data collected within the Polish Mother and Child Cohort (REPRO_PL). The analysis of PM_(10) impact on birth outcomes and children's health was restricted to 920 mother-child pairs. Daily PM_(10) exposure was calculated according to a predictive model in which the following variables were included: district, distance between place of residence and main road, house density, linear, quadratic, cubic trends and cyclic time trends. The average value of daily PM_(10) concentration in ambient air was 32μg/m~3. The association between PM_(10) concentration in the second trimester of pregnancy and birth length was of borderline significance (p=0.06). The other assessments based on REPRO_PL cohort confirmed statistically significant relationship between PAH metabolites and cotinine level in pregnancy and the child cephalization index (p=0.04). Higher prenatal PAH metabolite concentrations increased the risk of more frequent (≥1/year) respiratory infections in children during the first year of life. Presented study provides evidence that PM_(10) and PAH exposure in pregnancy might adversely affect fetal development and children's health.
机译：本研究的目的是评估暴露于环境空气污染和妊娠期，出生结果和儿童健康之间的关联。该研究基于在波兰母和儿童队列（Repro_pl）内收集的数据。 PM_（10）对出生结果和儿童健康的影响分析仅限于920对。每日PM_（10）曝光是根据预测模型计算的，其中包括以下变量：区，居住地和主要道路之间的距离，房屋密度，线性，二次，立方趋势和循环时间趋势。环境空气中每日PM_（10）浓度的平均值为32μg/ m〜3。 PM_（10）浓度之间的关联在怀孕和出生长度的第二个妊娠中的临界意义（p = 0.06）。基于REPRO_PL队列的其他评估确认了PAH代谢物和妊娠中的胞苷和细胞素水平之间的统计学意义关系和儿童头部骨质指数（P = 0.04）。较高的产前PAH代谢物浓度增加了生命的第一年中儿童更频繁（≥1/年）呼吸道感染的风险。提出的研究提供了证据表明PM_（10）和妊娠的PAH暴露可能会对胎儿发育和儿童的健康产生不利影响。

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