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Chip Based Microelectrochemical Cell Array for Whole-Cell Patch-Clamp Recording

机译：基于芯片的微电化学细胞阵列用于全细胞膜片钳记录

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摘要

High electrostablity and a long life-time of the devices are crucial for ionic current recording through ion channel proteins embedded in biological cell membrane based on planar chip technology for electrophysiological measurements. In this paper, we propose a novel planar microchip integrated with microelectrochemical cell array to more toward a feasible solution for ion channel screening with high resolution and long life-time. Through this chip based method, stable current recording through biological cell membrane is achieved with good electrical sealing resistance. In addition, with no need for complex fluidic connections, this method allows for an easy operation and further miniaturization of the measuring system.

机译：该设备的高电稳定性和长寿命对于通过基于平面芯片技术进行电生理测量的生物细胞膜中嵌入的离子通道蛋白记录离子电流至关重要。在本文中，我们提出了一种集成有微电化学电池阵列的新型平面微芯片，以期朝着高分辨率和长寿命的离子通道筛选的可行解决方案发展。通过这种基于芯片的方法，可以通过生物细胞膜实现稳定的电流记录，并具有良好的电密封性。另外，由于不需要复杂的流体连接，该方法使得操作简便并且测量系统进一步小型化。

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《》|2019年|1005-1008|共4页
会议地点 Berlin(DE)
作者
Tianyang Zheng; Gerhard Baaken; Jürgen Rühe; Jan C. Behrend; Rong Zhu;
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作者单位

State Key Laboratory of Precision Measurement Technology and Instruments Tsinghua University Beijing China;

Laboratory for Membrane Physiology and - Technology Institute of Physiology University of Freiburg Freiburg Germany;

Laboratory for Chemistry and Physics of interfaces University of Freiburg Freiburg Germany;

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Microelectrodes; Ions; Biomembranes; Semiconductor device measurement; Physiology; Current measurement;

机译：微电极离子；生物膜；半导体器件测量；生理;电流量测;

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专利

1. Microelectrochemical cell arrays for whole-cell currents recording through ion channel proteins based on trans-electroporation approach [J] . The Analyst: The Analytical Journal of the Royal Society of Chemistry: A Monthly International Publication Dealing with All Branches of Analytical Chemistry . 2020,第1期

机译：基于跨电电穿孔方法通过离子通道蛋白记录的全电池电流的微电色细胞阵列
2. Correction: Microelectrochemical cell arrays for whole-cell currents recording through ion channel proteins based on trans-electroporation approach [J] . Tianyang Zheng, Gerhard Baaken, Jan C. Behrends, The Analyst: The Analytical Journal of the Royal Society of Chemistry: A Monthly International Publication Dealing with All Branches of Analytical Chemistry . 2020,第4期

机译：校正：微电子化学电池阵列，用于通过离子通道蛋白质通过离子通道蛋白质记录的全电池电流
3. Microelectrochemical cell arrays for whole-cell currents recording through ion channel proteins based on trans-electroporation approach [J] . Tianyang Zheng, Gerhard Baaken, Jan C. Behrends, The Analyst: The Analytical Journal of the Royal Society of Chemistry: A Monthly International Publication Dealing with All Branches of Analytical Chemistry . 2020,第5期

机译：基于跨电电穿孔方法通过离子通道蛋白记录的全电池电流的微电色细胞阵列
4. Chip Based Microelectrochemical Cell Array for Whole-Cell Patch-Clamp Recording [C] . Tianyang Zheng, Gerhard Baaken, Jürgen Rühe, International Conference on Solid-State Sensors, Actuators and Microsystems amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp; Eurosensors . 2019

机译：用于全电池贴片夹具的芯片微电色化学电池阵列
5. A Novel Electrode to Improve Whole-Cell Patch-Clamp Recording [D] . Inayat, Samsoon 2011

机译：改善全细胞膜片钳记录的新型电极
6. Repeated whole-cell patch-clamp recording from CA1 pyramidal cells in rodent hippocampal slices followed by axon initial segment labeling [O] . Laura S. Oliveira, Anna Sumera, Sam A. Booker 2021

机译：在啮齿动物海马切片中的Ca1金字塔细胞重复全细胞贴片夹具然后是Axon初始段标记
7. Retraction: Microelectrochemical cell arrays for whole-cell currents recording through ion channel proteins based on trans-electroporation approach [O] . Tianyang Zheng, Gerhard Baaken, Jan C. Behrends, 2020

机译：缩回：基于反式电穿孔方法通过离子通道蛋白记录的全电池电流的微电子细胞阵列

Chip Based Microelectrochemical Cell Array for Whole-Cell Patch-Clamp Recording

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