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首页> 外文会议>Joint annual meeting of the International Society of Exposure Science and the International Society for Environmental Epidemiology >Simplified method for oral bioaccessibility of metal(loid)s in soils and alternative to the Unified Barge Method
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Simplified method for oral bioaccessibility of metal(loid)s in soils and alternative to the Unified Barge Method

机译：统一驳船方法中金属（懒惰）S的口服生物（LOID）S的简化方法及统一驳船方法

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Incidental ingestion of soil can expose people to toxic metal(loid)s, especially on contaminated sites. Oral bioaccessibility, i.e. the fraction of a soil contaminant that is solubilised in the digestive fluids after ingestion, is recommended to refine exposure and risk assessments. Reference method is the Unified Barge Method (UBM) validated for As, Cd and Pb against in vivo measurement. However, UBM is a complex method that implies high technical skills and needs numerous reagents. The objective of the present study is to test different chemical extractions using acetic acid (0.11 M), citric acid (0.11 M), EDTA (0.16 M) and hydrochloric acid (0.65%) to mimic the bioaccessible fraction of As, Cd and Pb in 209 soil samples with a wide range of physicochemical parameters and metal(loid)s' concentrations. The underlying hypothesis is that pH of the simulated gastric step is the limiting condition that drives the bioaccessiblity of the soil contaminants on which the UBM validation study focused on (i.e. As, Cd and Pb). Linear regression was used to determine the most relevant single-extraction method(s) capable of solubilizing As, Cd and Pb similar as those measured in both gastric and gastrointestinal phases defined by UBM. Significant relationships were obtained between As, Cd and Pb extracted in gastric and gastrointestinal phases and using the single-extraction methods. The results showed that the dilute hydrochloric acid test could be used as a suitable proxy to assess the gastric bioaccessibility of As, Cd and Pb.
机译：偶然的土壤摄入可以使人们暴露于有毒的金属（懒惰），特别是在受污染的地方。口服生物可接受性，即在摄入后在消化液中溶解的土壤污染物的一部分，以改进暴露和风险评估。参考方法是统一的驳船方法（UBM），用于在体内测量中验证为AS，CD和PB。然而，UBM是一种复杂的方法，它意味着高的技术技能，需要许多试剂。本研究的目的是使用乙酸（0.11μm），柠檬酸（0.11m），EDTA（0.16μm）和盐酸（0.65％）来测试不同的化学提取以模仿AS，CD和Pb的生物可接受的分数在209个土壤样品中，具有广泛的物理化学参数和金属（懒惰）的浓度。潜在的假设是模拟胃步骤的pH是驱动UBM验证研究重点的土壤污染物的生物污染物的生物侵害的限制条件（即CD和Pb）。线性回归用于确定能够将CD和Pb溶解的最相关的单萃取方法，与UBM定义的胃肠和胃肠阶段中测量的那些相似的单一提取方法。在胃和胃肠阶段中提取的Cd和Pb之间获得显着关系，并使用单萃取方法。结果表明，稀盐酸试验可用作适当的代理，以评估AS，CD和Pb的胃生物能力。

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