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首页> 外文会议>Joint annual meeting of the International Society of Exposure Science and the International Society for Environmental Epidemiology >Relationship between Polybrominated Diphenyl Ether (PBDE) Levels in Maternal Serum and Fetal Tissues during Mid-Gestation of Pregnancy and Associations with Placental Biomarkers of Growth and Development
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Relationship between Polybrominated Diphenyl Ether (PBDE) Levels in Maternal Serum and Fetal Tissues during Mid-Gestation of Pregnancy and Associations with Placental Biomarkers of Growth and Development

机译：孕妇血清和胎儿组织中的多溴二苯醚（PBDE）水平的关系在妊娠期和胎标生长和发育中的胎盘生物标志物中的关系

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Polybrominated diphenyl ether (PBDE) compounds are flame retardant chemicals with adverse effects on brain development, which may be mediated by placental effects. Pharmacokinetic factors may lead to disproportionate exposure in the developing fetus, yet the maternal-fetal relationship is not well understood. We examined whether PBDE concentrations vary between mother and fetus during early-to-mid pregnancy and identified placental biomarkers of PBDE exposure that may influence placental growth and function using statistical methods that account for left censored PBDE data. We calculated correlations between levels of 19 PBDE congeners across three biological matrices (maternal serum, placenta tissue, and fetal liver) in 130 maternal-fetal units. We conducted an exploratory analysis in a subset of samples to identify biomarkers of PBDE exposures that may influence placental development and function. Detection frequency was highest for BDE-47 (> 93% across matrices). Congener BDE-28 was more highly detected in placental and fetal liver tissues than maternal serum (> 60% compared to < 20%). PBDE levels were similar or higher in maternal compared to placental and fetal tissues before and after lipid adjustment for most congeners. The median BDE-47 concentration in serum was 0.24 ng/g (95% CI: 0.22, 0.28), more than twice as high as the placental value of 0.10 ng/g (95% CI: 0.09, 0.12). The difference was more pronounced after lipid adjustment, with 35.5 ng/g lipid BDE-47 found in serum compared to 10.8 ng/g in the placenta. Lipid-adjusted BDE-28, -99, and -153 levels were ～ two times higher in the placenta and fetal liver. Biomarker changes were observed in a subset of 12 placental tissues. Prenatal PBDE exposures are correlated with maternal levels. Molecular biomarkers related to placental development and function may be informative measures of PBDE exposure in future studies.
机译：聚溴二苯醚（PBDE）化合物是对脑发育不利影响的阻燃化学品，其可能通过胎盘效应介导。药代动力学因子可能导致发展胎儿中的暴露不成比例，但母亲胎儿关系并不充分了解。我们检查了在早期妊娠早期妊娠期间母亲和胎儿之间是否有所不同，并通过统计方法影响胎盘生长和功能的PBDE暴露的胎盘生物标志物，该统计方法考虑了左缩短了PBDE数据。在130个母体单位中，我们计算了三种生物学矩阵（母体血清，胎盘组织和胎儿肝脏）之间的19个PBDE同源物之间的相关性。我们在样品的子集中进行了探索性分析，以鉴定可能影响胎盘发育和功能的PBDE暴露的生物标志物。 BDE-47的检测频率最高（矩阵跨矩阵93％）。在胎儿和胎儿肝组织中更高度检测到的Congener BDE-28比母体血清（> 60％相比<20％）。与脂质调节之前和之后的胎盘和胎儿组织相比，母体的PBDE水平相似或更高。血清中的中位BDE-47浓度为0.24ng / g（95％Ci：0.22,0.28），胎盘值的两倍多为0.10ng / g（95％Ci：0.09,0.12）。脂质调节后差异更明显，血清中发现35.5 ng / g脂质BDE-47，而胎盘中的10.8 ng / g。胎盘和胎儿肝脏的脂质调节的BDE-28，-99和-153水平〜2倍。在12个胎盘组织的子集中观察到生物标志物变化。产前PBDE暴露与母体水平相关。与胎盘开发和功能相关的分子生物标志物可能是未来研究中PBDE暴露的信息措施。

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