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首页> 外文会议>Microfluidics, BioMEMS, and Medical Microsystems IV >Injection and manipulation of silicon microbeads in a customized microfluidic platform
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Injection and manipulation of silicon microbeads in a customized microfluidic platform

机译：在定制的微流体平台中注射和处理硅微珠

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摘要

The first on-chip injection and manipulation of optically encoded, silicon microbeads in a microfluidic platform is reported. Encoded microbeads of different shapes and sizes were fabricated in silicon via standard microfabrication techniques. The optical signature consisted of a series of lithographically defined bar-codes, which can be identified by a laser detection system. In-situ identification of encoded microbeads was possible at microbead velocities ≤ 50 cm per second. The microbeads can also be transported within a channel network in accordance with the encoded optical signature of each bead. The microbead transport is controlled by the laminar flow of a liquid in pressure driven microchannels. Hydrodynamic pulsing facilitated single and multiple injection of microbeads from a reservoir into the laminar fluid stream of a branched microfluidic network. Careful control of the fluid velocity and alteration of the microchannel geometry also enabled manipulation of microbead velocity. The incorporation of five pillars to retain microbeads at a specific location within the microchannel network formed the basis of a reaction chamber for on chip functionalization of microbeads. The principle of hydrodynamic switching was utlized to re-direct the transport of microbeads at a branched microfluidic network. In the final part of this research we verify that this microbead technology is suitable for detection of specific target DNA.
机译：据报道，在微流体平台上首次对光学编码的硅微珠进行片上注入和操作。通过标准微加工技术，在硅中制造了不同形状和大小的编码微珠。光学签名由一系列光刻定义的条形码组成，可以通过激光检测系统进行识别。在每秒小于或等于50 cm的微珠速度下，可以原位识别编码的微珠。微珠也可以根据每个珠的编码光学签名在通道网络内运输。微珠的运输是由压力驱动的微通道中液体的层流控制的。流体动力脉冲有助于将微珠从储层单次或多次注入分支微流网络的层流中。对流体速度的仔细控制和微通道几何形状的改变也使得能够操纵微珠速度。结合五个支柱以将微珠保留在微通道网络内的特定位置，形成了用于微珠芯片上功能化的反应室的基础。利用流体力学转换原理来重定向微珠在分支微流体网络上的运输。在本研究的最后部分，我们验证了这种微珠技术适用于检测特定的目标DNA。

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