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首页> 外文会议>Microfluidics, BioMEMS, and Medical Microsystems V; Proceedings of SPIE-The International Society for Optical Engineering; vol.6465 >Using a CD-like Microfluidic Platform for Uniform Calcium Alginate Drug Carrier Generation
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Using a CD-like Microfluidic Platform for Uniform Calcium Alginate Drug Carrier Generation

机译：使用类似CD的微流控平台来生成一致的藻酸钙药物载体

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In this paper the manipulation of monodisperse Ca-alginate microparticles using a polymer-based CD-like microfluidic platform and a reaction of external gelation is presented. Our strategy was based on associating the rapid injection molding process for cross-junction microchannel with the sheath focusing effect to form uniform water-in-oil (w/o) emulsions. These fine emulsions, consisting of 1.5% w/v Na-alginate, were then dripped into an oil solution containing 20% w/v calcium chloride (CaCl_2) to accomplish Ca-alginate microspheres in an efficient manner. We have demonstrated that one can control the size of Ca-alginate microparticles from 20 μm to 50 μm in diameter (with a variation less than 10%) by altering the relative sheath/sample flow rate ratio. Experimental data showed that for a given fixed dispersed phase flow (sample flow), the emulsion size decreased as the average velocity of the continuous phase (oil flow) increased. The proposed CD-like microfluidic platform is capable of generating relatively uniform micro-droplets and has the advantages of active control of droplet diameter, simple and low cost process, and high throughput.
机译：本文介绍了使用基于聚合物的CD样微流控平台和外部凝胶化反应的单分散海藻酸钙微粒的操作。我们的策略基于将交叉点微通道的快速注射成型工艺与鞘层聚焦效应相关联，以形成均匀的油包水（w / o）乳液。然后将这些由1.5％w / v海藻酸钠组成的细乳液滴入含有20％w / v氯化钙（CaCl_2）的油溶液中，以有效地制备Ca-藻酸盐微球。我们已经证明，通过改变鞘/样品的相对流速比，可以将钙藻酸盐微粒的尺寸控制在直径20μm至50μm（变化小于10％）。实验数据表明，对于给定的固定分散相流（样品流），随着连续相平均速度（油流）的增加，乳液尺寸减小。所提出的类CD微流体平台能够产生相对均匀的微液滴，并且具有主动控制液滴直径，简单和低成本过程以及高通量的优点。

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