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首页> 外文期刊>RSC Advances >Microfluidic spinning of fibrous alginate carrier having highly enhanced drug loading capability and delayed release profile
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Microfluidic spinning of fibrous alginate carrier having highly enhanced drug loading capability and delayed release profile

机译：海藻酸纤维载体的微流体纺丝具有高度增强的载药能力和延迟释放特性

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Natural polymer-based drug carriers have been developed for antimicrobial applications but several problems remain with their poor controllability of drug loading and degradation. We introduce a novel method to produce improved antibiotic alginate fiber with high drug entrapment properties and a delayed degradation profile. A microfluidic spinning system with a low-polarity isopropyl alcohol (IPA) sheath flow was used to dehydrate an alginate/ampicillin aqueous solution and to form densely packed fiber with enhanced drug loading efficiency. The amounts of ampicillin initially loaded in the IPA-fiber were much higher than in the conventional water-based fiber and they released a more prolonged profile. The fibers were characterized by analyzing the morphology, mass loss and structural properties. The fibers were also used for an in vivo infected wound healing study. The results showed that the IPA-based fibrous alginate drug carrier possesses superior properties for loading drugs and potentials for wound healing applications with easy management.
机译：已经开发了用于抗菌应用的基于天然聚合物的药物载体，但是由于它们对药物装载和降解的可控性差而仍然存在一些问题。我们介绍了一种新的方法来生产具有高药物截留性能和延迟降解特性的改良抗生素藻酸盐纤维。使用具有低极性异丙醇（IPA）鞘流的微流体纺丝系统对藻酸盐/氨苄青霉素水溶液进行脱水，以形成密堆积的纤维，从而提高了药物装载效率。最初装载在IPA纤维中的氨苄青霉素的量比常规水基纤维中的含量高得多，并且释放的时间更长。通过分析形态，质量损失和结构特性来表征纤维。纤维还用于体内感染伤口愈合研究。结果表明，基于IPA的纤维状藻酸盐药物载体具有优异的载药性能和易于治疗的伤口愈合应用潜力。

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