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首页> 外文会议>Molecular-Guided Surgery: Molecules, Devices, and Applications III >A tale of two photons: radioluminescence and its application in molecular imaging
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A tale of two photons: radioluminescence and its application in molecular imaging

机译：两个光子的故事：放射发光及其在分子成像中的应用

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摘要

Optical and ionizing radiation are two physical ways in which we can probe the living world. Until recently, these forms of radiation were used in distinct imaging and therapeutic applications-radiation therapy, photodynamic therapy, X-ray imaging, and diffuse optical tomography, to name a few. It has now been recognized that physical phenomena in which ionizing radiation and light are inherently coupled may provide powerful new capabilities for imaging and treating diseases. This presentation will review the physics and applications of radioluminescence, with a particular focus on molecular imaging. One such method, X-ray luminescence computed tomography (XLCT), uses narrow kilovolt X-ray beams to stimulate optical emissions from biologically targeted radioluminescent nanoparticles, thus providing high-resolution images even deep in tissue. A different phenomenon, Cherenkov luminescence, can also be harnessed to localize radiopharmaceuticals in vivo, allowing surgeons to visualize the molecular status of the tissues they are resecting. Recent progress towards routine implantation of these methods will be reviewed and sources of endogenous radioluminescence signal will be discussed.
机译：光学辐射和电离辐射是我们探索生活世界的两种物理方式。直到最近，这些形式的辐射还用于不同的成像和治疗应用中，例如辐射疗法，光动力疗法，X射线成像和漫射光学层析成像等。现在已经认识到，电离辐射和光固有地耦合的物理现象可以提供用于成像和治疗疾病的强大的新能力。本演讲将回顾放射发光的物理和应用，特别是分子成像。一种这样的方法，即X射线荧光计算机断层扫描（XLCT），它使用狭窄的千伏X射线束来激发生物靶向放射发光纳米粒子发出的光发射，从而提供甚至在组织深处的高分辨率图像。切伦科夫发光是一种不同的现象，也可以用来在体内定位放射性药物，使外科医生可以观察到要切除的组织的分子状态。将回顾这些方法常规植入的最新进展，并讨论内源性放射发光信号的来源。

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