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首页> 外文会议>Multifunctional polymer-based materials. >Swelling and Release Properties of Functional K-carrageenan Hydrogel Nanocomposites
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Swelling and Release Properties of Functional K-carrageenan Hydrogel Nanocomposites

机译：功能性卡拉胶水凝胶纳米复合材料的溶胀和释放特性

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摘要

Today polysaccharide based hydrogel nanocomposites are receiving high importance as biomaterials for drug delivery. Inorganic nanoparticles (NPs) are incorporated into the polymer matrix to provide novel functionalities to the hydrogels. However, the effect of nanofillers on the release properties has not been totally understood. In this work, we investigate the influence of inorganic functional nanofillers (Fe_3O_4 and Au NPs) with variable size and shape on the structure of K-carrageenan hydrogels and on the kinetics and release mechanism of methylene blue (MB) as model drug. It was shown that, depending on the nature of the nanofiller incorporated, and for equivalent nanofiller content, the mechanism of MB release can be adjusted either to by diffusion or polymer relaxation mechanism. The mechanism of the MB release was found to be determined by the strength and microstructure of the gel network and extent of gel swelling, which are affected by the extent of incorporation of the nanofillers.
机译：如今，基于多糖的水凝胶纳米复合材料作为药物递送的生物材料正受到高度重视。将无机纳米颗粒（NPs）掺入聚合物基质中，为水凝胶提供新颖的功能。但是，纳米填料对释放性能的影响尚未完全了解。在这项工作中，我们研究了具有可变大小和形状的无机功能性纳米填料（Fe_3O_4和Au NPs）对K-卡拉胶水凝胶的结构以及作为模型药物的亚甲基蓝（MB）动力学和释放机理的影响。结果表明，取决于所掺入的纳米填料的性质以及对于等效的纳米填料含量，MB释放的机理可以通过扩散或聚合物松弛机理进行调节。发现MB释放的机理取决于凝胶网络的强度和微结构以及凝胶溶胀程度，这受纳米填料掺入程度的影响。

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  • 来源
  • 会议地点 Boston MA(US);Boston MA(US)
  • 作者

    Ana Luisa Daniel da Silva; Ana M. Salgueiro; Sara Fateixa; Joana Moreira; Ana C. Estrada; Ana M. Gil; Tito Trindade;

  • 作者单位

    CICECO and Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal;

    CICECO and Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal;

    CICECO and Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal;

    CICECO and Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal;

    CICECO and Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal;

    CICECO and Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal;

    CICECO and Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 材料;材料;
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