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首页> 外文会议>Nano- and Microelectromechanical Systems (NEMS and MEMS) and Molecular Machines >A Chemical Sensor Using Neurons and a 3-D Micro-fluidic Chip
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A Chemical Sensor Using Neurons and a 3-D Micro-fluidic Chip

机译：使用神经元和3-D微流控芯片的化学传感器

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In recent years, there has been a merger of microelectronics and biological sciences to develop integrated nano and micro-scale biosensors or biochips. The implementation of portable, rapid and economic methods for detecting different biological species on a chip will benefit from the development of electronic means for the analysis of cells. Neurons are very attractive as chemical sensors due to their sensitivity to specific toxins and their unique electrical properties. The use of closed well micro-fluidic devices for the growth of neurons has not been explored extensively. In this work, we will describe surface preparation techniques to enhance the neuronal cell viability and growth on microfabricated surfaces. We have fabricated micro-fluidic bio-chips for the trapping of neurons and to examine their growth. Neural cells are maintained in a chamber on the chip with fresh nutrient media continuously flowing through the chamber. The temporal viability of the neural cells within the chip will be reported. The long-term goals of the project include electrically measuring the viability of the cells inside the micro-fluidic chambers.
机译：近年来，微电子学和生物科学已经融合在一起，以开发集成的纳米和微型生物传感器或生物芯片。用于检测芯片上不同生物物种的便携式，快速且经济的方法的实施将受益于用于细胞分析的电子手段的发展。由于神经元对特定毒素的敏感性及其独特的电学性质，其作为化学传感器非常有吸引力。封闭孔微流体装置用于神经元生长的用途尚未广泛探索。在这项工作中，我们将描述表面处理技术，以增强神经元细胞的活力和在微型表面上的生长。我们已经制造出用于捕获神经元并检查其生长的微流控生物芯片。神经细胞被维持在芯片上的腔室中，新鲜的营养介质连续流过该腔室。将报告芯片内神经细胞的时间生存力。该项目的长期目标包括用电测量微流室内的细胞活力。

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