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首页> 外文会议>Colloidal nanoparticles for biomedical applications XIII >Combined photothermo-chemotherapy using gold nanoshells on drug- loaded micelles for colorectal cancer treatment
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Combined photothermo-chemotherapy using gold nanoshells on drug- loaded micelles for colorectal cancer treatment

机译：在载药胶束上使用金纳米壳的光热化学疗法联合治疗大肠癌

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Combined photothermo-chemotherapy is a new strategy for cancer treatment which improves the therapeutic outcome by synergistic effects of both therapies. Here, we presented a multifunctional gold nanoshell that exhibited excellent photothermal conversion and delivered the hydrophobic chemotherapy drug, SN-38. The positively charged SN-38-loaded PDMA-PCL micelles were decorated with a gold layer by in situ reduction of chloroauric acid on the surface of micelles. Scanning and transmission electron microscopy images proved micelles were successfully decorated and the resulting gold nanoshells had a spherical morphology with a narrow size distribution. The synthesized gold nanoshells displayed a broad surface plasmon resonance peak in the near-infrared wavelength region and a great photothermal conversion ability. After pegylation, gold nanoshells were stable in biological media and appeared highly biocompatible in the absence of laser irradiation. Upon near-infrared laser irradiation, incident energy was converted into heat by gold nanoshells on SN-38-loaded micelles (SN-38@pGNS), which causes local temperature increase and triggers the release of encapsulated drug. Compared to SN-38, SN-38-loaded micelles, or laser with drug-free gold nanoshells alone, combined photothermo-chemotherapy using SN-38@pGNS with laser irradiation killed colorectal cancer cells with higher efficacy in vitro and demonstrated significant tumor suppression in vivo, suggesting that gold nanoshells on drug-loaded micelles delivered SN-38 and photothermal therapy in synergistic actions and might be a potential candidate for future colorectal cancer therapy.
机译：联合光热化学疗法是一种新的癌症治疗策略，可通过两种疗法的协同作用改善治疗效果。在这里，我们介绍了一种多功能的金纳米壳，该壳表现出出色的光热转化率并提供了疏水化学药物SN-38。通过在胶束表面原位还原氯金酸，将带正电荷的SN-38负载PDMA-PCL胶束装饰有金层。扫描和透射电子显微镜图像证明，胶束被成功地修饰，并且所得的金纳米壳具有窄尺寸分布的球形形态。合成的金纳米壳在近红外波长区域表现出宽的表面等离子体共振峰，并具有良好的光热转化能力。在聚乙二醇化之后，金纳米壳在生物介质中稳定并且在没有激光照射的情况下表现出高度的生物相容性。在近红外激光照射下，金纳米壳在负载SN-38的胶束（SN-38 @ pGNS）上将入射能量转换为热量，这导致局部温度升高并触发了封装药物的释放。与SN-38，负载SN-38的胶束或单独使用不含药物的金纳米壳进行激光处理相比，使用SN-38 @ pGNS与激光照射联合光热化学疗法可在体外杀死结肠直肠癌细胞，具有更高的功效，并显示出显着的肿瘤抑制作用在体内，这表明载有药物的胶束上的金纳米壳以协同作用传递了SN-38和光热疗法，并可能成为未来大肠癌治疗的潜在候选者。

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