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首页> 外文会议>Nanotechnology amp; applications >HIGH-PERFORMANCE CARBON NANOTUBE FIELD-EFFECT TRANSISTORS FOR HIGH-SENSITIVE BIOSENSORS
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HIGH-PERFORMANCE CARBON NANOTUBE FIELD-EFFECT TRANSISTORS FOR HIGH-SENSITIVE BIOSENSORS

机译：用于高灵敏度生物传感器的高性能碳纳米管场效应晶体管

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摘要

Carbon nanotube field-effect transistors (CNTFETs) with local electrolyte gated in solution provided high performance in terms of subthreshold slope and transconductance, resulting from the modulation of the conduction in the carbon nanotube channel and the large gate capacitance. Using the CNTFETs, label-free protein biosensors have been fabricated to detect immunoglobulin E (IgE), in which CNT channels were modified with aptamers. Since aptamers are artificial oligonucleotides, the aptamers are smaller in size than the Debye length. Therefore, the biosensors are expected to detect IgE with high sensitivity. After the 5'- amino modified aptamers were covalcntly immobilized on the CNT channels, the electrical properties of the CNTFETs were monitored in real time. The introduction of target IgE at various concentrations caused a sharp decrease in the source-drain current and gradual saturation at lower values. From electrical measurements in IgE concentration dependent, the association constant between IgE molecules and IgE aptamcr could be calucated to be 5.14 × 10~8 (M~(-1)) using the Langmuir adsorption isotherm.
机译：碳纳米管场效应晶体管（CNTFET）具有在溶液中门控的局部电解质，在亚阈值斜率和跨导方面提供了高性能，这归因于碳纳米管通道中的导电调制和大的栅极电容。使用CNTFET，已经制造了无标记的蛋白质生物传感器来检测免疫球蛋白E（IgE），其中CNT通道被适体修饰。由于适体是人工寡核苷酸，因此适体的大小小于德拜长度。因此，期望生物传感器以高灵敏度检测IgE。在将5'-氨基修饰的适体共价固定在CNT通道上后，实时监测CNTFET的电性能。以不同浓度引入目标IgE会导致源极-漏极电流急剧下降，并在较低值时逐渐饱和。根据电学测量值（取决于IgE浓度），使用Langmuir吸附等温线可将IgE分子与IgE适体之间的缔合常数计算为5.14×10〜8（M〜（-1））。

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