Phosphorothioate oligonucleotides as aptamers of retroviral reverse transcriptases

机译：硫代磷酸酯寡核苷酸作为逆转录病毒逆转录酶的适体

获取原文

获取原文并翻译 | 示例

页面导航

摘要
著录项
相似文献
相关主题

摘要

Retroviral reverse transcriptases catalyze the synthesis of a double-stranded DNA copy of the RNA genome for integration into host chromosome. These enzymes possess three enzymatic activities essential for retrovirus replication: an RNA-dependent DNA polymerase, a DNA-dependent DNA polymerase which synthesizes the second strand of the proviral DNA, and an RNase H which degrades RNA template after the synthesis of the first strand of the proviral DNA. The importance of reverse transcriptase (RT) in the life cycle of retroviruses (e.g. HIV) makes the enzyme a preferred target for antiviral strategies.

机译：逆转录病毒逆转录酶催化RNA基因组双链DNA拷贝的合成，以整合到宿主染色体中。这些酶具有逆转录病毒复制所必需的三种酶活性：RNA依赖的DNA聚合酶，合成前病毒DNA的第二链的DNA依赖的DNA聚合酶，以及在合成第一条病毒后降解RNA模板的RNaseH。原病毒DNA。逆转录酶（RT）在逆转录病毒（例如HIV）生命周期中的重要性使该酶成为抗病毒策略的首选靶标。

著录项

来源
《NATO Advanced Research Workshop on RNA Biochemistry and Biotechnology Poznan, Poland October 10-17, 1998》|1998年|p.315-324|共10页
会议地点 Poznan(PL)
作者
M. Koziolkiewicz; A. Krakowiak; A. Owczarek; M. Boczkowska;
展开▼
作者单位

展开▼
会议组织
原文格式 PDF
正文语种 eng
中图分类生物化学;
关键词

相似文献

外文文献
中文文献
专利

1. Phosphorothioate-modified antisense oligonucleotides against human telomerase reverse transcriptase sensitize cancer cells to radiotherapy [J] . Cao Fei, Ju Xiaoping, Chen Di, Molecular medicine reports . 2017,第2aPta2期

机译：针对人端粒酶逆转录酶的硫代磷酸酯改性的反义寡核苷酸敏化癌细胞以放射治疗
2. Evaluation of an oligonucleotide ligation assay for detection of mutations in HIV-1 subtype C individuals who have high level resistance to nucleoside reverse transcriptase inhibitors and non-nucleoside reverse transcriptase inhibitors. [J] . Wallis CL, Mahomed I, Morris L, Journal of Virological Methods . 2005,第2期

机译：评估寡核苷酸连接测定法，以检测对核苷类逆转录酶抑制剂和非核苷类逆转录酶抑制剂具有高水平耐药性的HIV-1亚型C个体中的突变。
3. Novel combinatorial selection of phosphorothioate oligonucleotide aptamers [J] . King DJ., Brasier AR., Gorenstein DG., Biochemistry . 1998,第47期

机译：硫代磷酸酯寡核苷酸适体的新型组合选择
4. Phosphorothioate oligonucleotides as aptamers of retroviral reverse transcriptases [C] . M. Koziolkiewicz, A. Krakowiak, A. Owczarek, NATO advanced research workshop on RNA biochemistry and biotechnology . 1999

机译：硫代磷酸寡核苷酸作为逆转录病毒逆转录酶的适体
5. Characterization of novel nucleic acid inhibitors (aptamers) of human immunodeficiency virus reverse transcriptase selected using a primer-free selex approach. [D] . Lai, Yi-Tak. 2011

机译：使用无引物selex方法选择的人类免疫缺陷病毒逆转录酶的新型核酸抑制剂（适体）的表征。
6. Phosphorothioate oligonucleotides derived from human immunodeficiency virus type 1 (HIV-1) primer tRNALys3 are strong inhibitors of HIV-1 reverse transcriptase and arrest viral replication in infected cells. [O] . R El Dirani-Diab, L Sarih-Cottin, B Delord, 1997

机译：源自人类免疫缺陷病毒1型（HIV-1）引物tRNALys3的硫代磷酸酯寡核苷酸是HIV-1逆转录酶的强抑制剂可阻止受感染细胞中的病毒复制。
7. Inhibition of human telomerase reverse transcriptase in vivo and in vitro for retroviral vector-based antisense oligonucleotide therapy in ovarian cancer [O] . Z Qi, R Mi 2016

机译：抑制人端粒酶逆转录酶体内和体外逆转录载体的反义寡核苷酸治疗卵巢癌

Phosphorothioate oligonucleotides as aptamers of retroviral reverse transcriptases

摘要

著录项

相似文献

相关主题

期刊订阅