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首页> 外文会议>NATO Advanced Study Institute on Polymer Based Systems on Tissue Engineering, Replacement and Regeneration Oct 15-25, 2001 Alvor, Algarve, Portugal >POLYMERIC MATRICES FOR RELEASE OF GROWTH FACTORS, HORMONES AND OTHER BIOACTIVE AGENTS
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POLYMERIC MATRICES FOR RELEASE OF GROWTH FACTORS, HORMONES AND OTHER BIOACTIVE AGENTS

机译：释放生长因子，激素和其他生物活性剂的聚合物基质

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摘要

The treatment, repair and regeneration of damaged tissues, which is the aim of modern tissue engineering, can be tailored to provide the optimum environment incorporating controlled release of the appropriate active compounds. In this sense, a big challenge is to optimize the delivery of immunosuppressors, hormones, growth factors, vitamins and other active agents. Great efforts are nowadays directed towards the preparation of matrices for the controlled delivery of this kind of compounds. Two basic types of delivery systems have to be taken into account: polymer-active covalent conjugates, and matrices that physically incorporate the drug. In both cases and for these particular applications, biodegradability (and/or resorbabilility), and biocompatibility are indispensable requirements since most of the times the biomaterial will be implanted OT parenterally administered. Examples of polymeric supports for chemically-linked bioactive compounds and physically-loaded systems are presented. A critical discussion of their advantages and practical problems is also included in this chapter.
机译：可以调整受损组织的处理，修复和再生，这是现代组织工程学的目标，可以定制以提供最佳环境，其中包含适当活性化合物的受控释放。从这个意义上讲，最大的挑战是优化免疫抑制剂，激素，生长因子，维生素和其他活性剂的递送。如今，人们致力于制备可控地递送这类化合物的基质。必须考虑两种基本类型的递送系统：聚合物活性共价结合物和物理掺入药物的基质。在这两种情况下以及对于这些特定应用，生物降解性（和/或再吸收性）和生物相容性都是必不可少的要求，因为大多数时间将生物材料植入肠胃外进行OT。给出了用于化学连接的生物活性化合物和物理负载系统的聚合物载体的实例。本章还包括对它们的优点和实际问题的严格讨论。

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