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Biofunctionalization of Nanoelectrode Ensembles: protection of the nanoelectrodes with self-assembled monolayers

机译：纳米电极组件的生物功能化：用自组装单层膜保护纳米电极

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In this work we study the possibility to use self-assembled monolayers (SAMs) of thiols to protect the surface of nanoelectrodes ensembles (NEEs) from the undesired adsorption of biomolecules, in particular, proteins. Thioctic acid (TA) and 2-mercaptoethanesulfonic acid (MES) were chosen for this aim. The behaviour of SAM-modified NEEs was studied by cyclic voltammetry as a function of the solution pH using ferrocenecarboxylate as anionic redox probe (FcCOO") and (ferrocenylmethyl) trimethylammonium (FA+) as cationic redox probe. It was observed that, when the SAM is negatively charged it repels the negative redox probes from the surface of the nanoelectrodes, while the voltammetry of FA+ remain unchanged. The possible protective role of the SAM was confirmed by studying the voltammetric signals recorded with NEEs dipped in a solution of a high adsorbable protein, namely casein, comparing signals recorded at bare NEEs vs. signals at SAM-modified NEEs, in different experimental conditions.
机译：在这项工作中，我们研究了使用硫醇的自组装单分子膜（SAMs）来保护纳米电极组件（NEEs）表面免受有害的生物分子（尤其是蛋白质）吸附的可能性。为此目的选择了硫辛酸（TA）和2-巯基乙磺酸（MES）。使用二茂铁羧酸盐作为阴离子氧化还原探针（FcCOO”）和（二茂铁基甲基）三甲基铵（FA +）作为阳离子氧化还原探针，通过循环伏安法研究了SAM修饰的NEE的行为随溶液pH的变化。负电荷可排斥纳米电极表面的负氧化还原探针，而FA +的伏安保持不变，SAM的可能的保护作用是通过研究用浸入高吸附蛋白溶液中的NEE记录的伏安信号来确认的，即酪蛋白，在不同的实验条件下，将裸NEE处记录的信号与SAM修饰NEE处的信号进行比较。

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