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NMR Imaging and Its Application in the Study of Pharmaceutical Tablets

机译：核磁共振成像及其在药物片剂研究中的应用

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摘要

NMR imaging is a non-destructive and non-invasive technique especially well suited to investigate the kinetics of water uptake, swelling and erosion of pharmaceutical tablets used for drug delivery. Polysaccharides such as high amylose starch, cellulose derivatives and chitosan have been used as excipients in the tablets for the controlled release of drugs. NMR imaging may be used to quantitatively study the swelling of the compressed polymer tablets and the penetration of water in the polymer matrices. These results help to elucidate the effects of temperature, tablet size and drug loading on the properties and drug release process of the tablets. The new physicochemical understanding gained with NMR imaging techniques may help in the design and development of new oral tablets for more efficient drug delivery.
机译：NMR成像是一种非破坏性和非侵入性技术，特别适合用于研究用于药物递送的药物片剂的吸水，溶胀和腐蚀动力学。诸如高直链淀粉，纤维素衍生物和壳聚糖之类的多糖已被用作片剂中的赋形剂，用于药物的控释。 NMR成像可用于定量研究压缩的聚合物片剂的溶胀和水在聚合物基质中的渗透。这些结果有助于阐明温度，片剂大小和载药量对片剂性质和药物释放过程的影响。通过NMR成像技术获得的新的理化理解可能有助于设计和开发新型口服片剂，以实现更高效的药物递送。

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