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Application of slurry bridging experiments at controlled water activities to analyze the phase conversion between anhydrous and hydrated ciprofloxacin

机译：浆液桥接实验在控制水活度中的应用，以分析无水和水合环丙沙星之间的相转化

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The hydration state of a hydrate depends on the water activity, aw, in the crystallization medium. Selection of an appropriate ratio of water to cosolvent in the crystallization medium of a hydrate is critical. This study attempts to elucidate this selection process by using slurry bridging at controlled water activity and studying the conditions of physical stability of the solid phases of ciprofloxacin, which comprise an anhydrate and a hydrate. If the system is not in equilibrium, a mixture of the anhydrate and the monohydrate may sometimes be obtained. The excess solid phase was characterized by powder X-ray diffractometry (PXRD), thermogravimetric analysis (TGA) and Differential scanning calorimetry (DSC). These results suggest that water activity is the major factor determining the nature of the solid phase of ciprofloxacin which crystallizes from methanol and water. The solubilities of the two solid forms in the mixed solvent system were also measured by HPLC and are discussed. The data suggest that the slurry bridging technique at controlled water activities provides an accurate method of rapidly predicting the physically stable form in anhydrous/hydrate systems.

机译：水合物的水合状态取决于结晶介质中的水活度aw。在水合物的结晶介质中选择合适的水与助溶剂的比例至关重要。这项研究试图通过在受控水活度下使用淤浆桥接并研究环丙沙星固相的物理稳定性条件（包括无水物和水合物）来阐明这一选择过程。如果系统不平衡，则有时会获得无水物和一水合物的混合物。多余的固相通过粉末X射线衍射法（PXRD），热重分析（TGA）和差示扫描量热法（DSC）表征。这些结果表明水活度是决定环丙沙星固相性质的主要因素，环丙沙星从甲醇和水中结晶出来。还通过HPLC测量了两种固体形式在混合溶剂体系中的溶解度并进行了讨论。数据表明，在受控水活度下的浆液桥接技术提供了一种快速预测无水/水合物系统中物理稳定形式的准确方法。

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《Novel Drug Delivery Systems: Research and Application》|2007年|193-201|共9页
会议地点 Shanghai(CN)
作者
Brendan BOYLE; rnStephen NICHOLAS;
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作者单位

Xianwen Li@Department of Chemistry and Chemical Engineering, Minjiang University, No.1, Wenxian Road, Shangjie Town, Minhou County, Fuzhou, Fujian 350108, PR China--Jian Zhang@State Key Laboratories of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, PR China--Yiqiao Hu@State Key Laboratories of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, PR China--;

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正文语种 eng
中图分类药剂学;
关键词
Hydrate; Anhydrate; Water activity; Ciprofloxacin; State rnconversion; Slurry bridging;

机译：水合物;无水;水活度;环丙沙星;状态转化;浆液桥接;

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1. Application of slurry bridging experiments at controlled water activities to predict the solid-state conversion between anhydrous and hydrated forms using theophylline as a model drug. [J] . Ticehurst MD, Storey RA, Watt C International Journal of Pharmaceutics . 2002,第1a2期

机译：浆液桥接实验在受控水活度中的应用，以茶碱为模型药物，预测无水和水合形式之间的固态转化。
2. Investigating hydrate formation rate and the viscosity of hydrate slurries in water-dominant flow: Flowloop experiments and modelling [J] . Sakurai Shunsuke, Ben Hoskin, Choi Joel, Fuel . 2021,第MAYa15期

机译：水合物形成率和水性浆液中水合物浆液的粘度：流动的实验和建模
3. Measurement of the water droplet size in water-in-oil emulsions using low field nuclear magnetic resonance for gas hydrate slurry applications [J] . Majid Ahmad A. A., Saidian Milad, Prasad Manika, Canadian Journal of Chemistry . 2015,第9期

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4. Application of slurry bridging experiments at controlled water activities to analyze the phase conversion between anhydrous and hydrated ciprofloxacin [C] . International Pharmaceutical Symposium . 2007

机译：浆料桥接实验在受控水中的应用分析无水水合环丙沙星之间的相转化
5. Carbon dioxide hydrate formation in a three-phase slurry bubble column. [D] . Hashemi, Shahrzad. 2009

机译：在三相浆料鼓泡塔中形成二氧化碳水合物。
6. Direct determination of hydration in the interdigitated and ripple phases of dihexadecylphosphatidylcholine: hydration of a hydrophobic cavity at the membrane/water interface. [O] . S Channareddy, N Janes 1999

机译：直接测定二十六烷基磷脂酰胆碱的交叉相和波纹相中的水合：膜/水界面处疏水腔的水合。
7. Decision-making is the process of analyzing information about a problem situation and comparing it to a specific conclusion in order to solve a specific problematic (Yıkılmaz, 2001; Miller and Byrnes, 2001). Decision-making styles are a mechanism that is influenced by the internal and external conditions that determine the direction of the decisions of the individual, the content of the decision-making process, and the outcome of the decision-making process (Payne, Bettman and Johson, 1993; Bavol’ár and Orosová, 2015). ACT is a contemporary member of the Cognitive Behavioral Therapy family. ACT (Acceptance and commitment therapy) has both similar and different directions with Behavioral Therapies and Cognitive Therapies (Herbet and Forman, 2011; Hayes, 2004). KKT responds to classical behavioral treatments using both existential and cognitive approaches in the analysis of behavior. KKT is a science wing that tries to solve human problems with a wider perspective aimed at solving problematic human behaviors (Plumb, Stewart, Dahl and Lundgren, 2009). It is seen that there is very little research about the new approach of ACT approach when the aiming country of our country is screened and it is thought that our country will contribute to the field of psychological counseling with the work done. In the scope of the research, experimental and control groups and preliminary test, post-test and follow-up measurements of 2x3 experimental design were used. The study's study group consists of a total of 24 (12 experimental and 12 control groups) university students studying in different departments and levels, continuing their education in the academic year of 2015-2016 in Ağrı province and İbrahim Chechen University in 2015-2016 academic year. The average age of participants in the experiment and control group is 20. There were 12 participants in the experimental group, 7 female and 5 male, and 12 participants, 7 female and 5 male in the control group. Personal Information Form and Decision Making Style Scale prepared by the researcher were used in the research. In order to decide on the tests to be used in the course of analyzing the data, the scores of the participant's Decision Styles Scale pre-test, which are placed primarily in the experimental and control groups, it was analyzed whether the basic expectations of parametric tests were answered. As a result of the analysis made, the scores, skewness and kurtosis coefficients obtained from the Decision Making Styles Scale were given to the experimental and control groups. It was determined that the distribution was normal in the result of Shapiro-Wilk test, in which the skewness and kurtosis coefficients of each sub-scale were ranked between -1 and +1. 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The pre-test scores obtained from the rational decision-making style of the experimental and control groups showed that there was a difference between the post-test and the follow-up scores, but this difference was not significant. As a result of the analysis, it was determined that the test group had higher levels of rational decision style than the pre - test scores in the post test and follow - up scores, whereas the post test and follow - up test scores in the control group rational decision style showed a decrease compared to the pre - test scores. the pre - test scores. Decision-making Styles Scale Avoidant Decision Making As a result of the analysis of the mean scores of the subscale scores of pre-test, post-test and follow-up measures, the group effect was found to be insignificant. 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机译：决策是分析有关问题情况的信息并将其与特定结论进行比较的过程，以解决特定的问题（Yıkılmaz，2001; Miller和Byrnes，2001）。决策风格是一种机制，受到内部和外部条件的影响，确定个人决定的方向，决策过程的内容以及决策过程的结果（PAYNE，BETTMAN和BEDNE） Johson，1993;Bavol'ár和奥萨洛瓦，2015）。法案是认知行为治疗家庭的当代成员。行为（验收和承诺治疗）具有与行为疗法和认知疗法的类似和不同方向（Herbet和Forman，2011; Hayes，2004）。 KKT在分析行为中使用存在性和认知方法来响应古典行为治疗方法。 KKT是一个科学翼，试图解决人类问题，旨在解决有问题的人类行为（铅垂，斯图尔特，Dahl和Lundgren，2009）。有人认为，当我们国家的瞄准国家进行筛选时，有关行动方法的新方法几乎没有研究，并且认为我们的国家将为完成工作做出贡献的心理咨询领域。在研究的范围内，使用实验和对照组和初步测试，使用后测试和后续测量的2x3实验设计。该研究的研究小组包括共24名（12个实验和12个对照组）大学学生在不同的部门和水平上学习，在2015-2016学术上继续进行2015-2016的学术年度2015-2016学年年。实验和对照组参与者的平均年龄是20.实验组中有12名参与者，7名女性和5名男性，12名参与者，7名女性和5名男性。研究人员准备的个人信息表格和决策制定风格规模在研究中使用。为了决定在分析数据的过程中使用的测试，参与者的决策风格刻度预测的分数主要在实验和对照组中进行，分析了参数的基本期望吗？测试得到了回答。由于对实验和对照组给出了从决策曲调标度获得的分数，偏移和峰度分子系数。确定该分布是正常的在成熟的-WILK试验结果中，其中每亚级的偏差和刚度系数在-1到+1之间排名。实验和对照组的参与者;决策式预测测量的同质性测试结果表明数据是均匀的。根据毛毛环保试验的结果，已确定工作支持假设。据确定，从依赖决策风格的实验和对照组获得的预测分数之间没有显着差异，但测试组在测试后的分数内显示出较低的平均分数和后续的分数 - 测试。因此，可以说，应用于实验组的面向活动的心理教育程序减少了决策风格子维度的依赖决策风格分数，并且心理教育程序具有持久的效果。据确定，从实验和对照组自发决策风格获得的预测试，测试后和后续评分之间没有显着差异。因此，可以说这种情况不会导致从应用于实验组的活动导向的心理教育程序的决策风格分数的自发决策风格分数显着差异。行为的心理教育计划在个人直观的决策风格下降，但这种减少并没有产生显着的差异。因此，可以说，这种情况不会在从应用于实验组的KKT导向的心理教育程序的决策风格分数中产生有意义的决策风格分数。从实验和对照组的理性决策风格获得的预测分数显示后检验后和随访评分之间存在差异，但这种差异并不重要。由于分析，确定测试组的理性决策风格较高，而不是后测试和后续分数的预测分数，而对照组合理决策风格的后测试和后续测试分数显示出与预测试分数相比的减少。预测分数。决策款式扩展避免决策由于分析了预测试，测试后和后续措施的班次评分的平均分数，发现群体效应是微不足道的。确定实验和对照组从避免决策风格获得的预测评分中显着不同，但在测试后和后续测试的分数内没有显示出任何重大变化。
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机译：第1部分钠和氯离子运输的生理机制调查和盐水淡化的实验设计第2部分盐水转化中藻类使用的实验室评估第一阶段最终报告

Application of slurry bridging experiments at controlled water activities to analyze the phase conversion between anhydrous and hydrated ciprofloxacin

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