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Corneal Tissue Ablation using 6.1 μm quantum cascade laser

机译：使用6.1μm量子级联激光进行角膜组织消融

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摘要

High absorption property of tissues in the IR range (λ> 2 μm) results in effective tissue ablation, especially near 3 μm. In the mid-infrared range, wavelengths of 6.1 um and 6.45 μm fall into the absorption bands of the amide protein groups Amide-Ⅰ and Amide-Ⅱ , respectively. They also coincide with the deformation mode of water, which has an absorption peak at 6.1 μm. This coincidence makes 6.1 μm laser a better ablation tool that has promising effectiveness and minimum collateral damages than 3 μm lasers. In this work, we performed bovine corneal ablation test in-vitro using high-power 6.1 μm quantum cascade laser (QCL) operated at pulse mode. Quantum cascade laser has the advantages of low cost, compact size and tunable wavelength, which makes it great alternative Mid-IR light source to conventional tunable free-electron lasers (FEL) for medical applications. Preliminary results show that effective corneal stroma craters were achieved with much less collateral damage in corneal tissue that contains less water. Future study will focus on optimizing the control parameters of QCL to attain neat and precise ablation of corneal tissue and development of high peak power QCL.
机译：组织在IR范围（λ> 2μm）中的高吸收特性可有效消融组织，尤其是在3μm附近。在中红外范围内，波长为6.1 um和6.45μm的光分别落入酰胺蛋白质组Amide-Ⅰ和Amide-Ⅱ的吸收带中。它们还与水的变形模式一致，该水的吸收峰在6.1μm处。这种巧合使得6.1μm激光成为一种更好的消融工具，与3μm激光相比，它具有可观的效果和最小的附带损害。在这项工作中，我们使用在脉冲模式下运行的高功率6.1μm量子级联激光器（QCL）进行了牛角膜消融试验。量子级联激光器具有成本低，尺寸紧凑和波长可调的优点，这使其成为医疗应用中传统红外可调谐自由电子激光器（FEL）的绝佳替代中红外光源。初步结果表明，在含水量较少的角膜组织中，获得了有效的角膜基质弹坑，而附带损害却少得多。未来的研究将集中在优化QCL的控制参数上，以实现角膜组织的整洁和精确消融以及高峰值功率QCL的发展。

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