首页> 外文会议>Optical Coherence tomography and coherence domain optical methods in biomedicine XIX >Probing Myocardium Biomechanics using Quantitative Optical Coherence Elastography
【24h】

Probing Myocardium Biomechanics using Quantitative Optical Coherence Elastography

机译:使用定量光学相干弹性成像技术探测心肌生物力学

获取原文
获取原文并翻译 | 示例

摘要

We present a quantitative optical coherence elastographic method for noncontact assessment of the myocardium elasticity. The method is based on shear wave imaging optical coherence tomography (SWI-OCT), where a focused air-puff system is used to induce localized tissue deformation through a low-pressure short-duration air stream and a phase-sensitive OCT system is utilized to monitor the propagation of the induced tissue displacement with nano-scale sensitivity. The 1-D scanning of M-mode OCT imaging and the application of optical phase retrieval and mapping techniques enable the reconstruction and visualization of 2-D depth-resolved shear wave propagation in tissue with ultra-high frame rate. The feasibility of this method in quantitative elasticity measurement is demonstrated on tissue-mimicking phantoms with the estimated Young's modulus compared with uniaxial compression tests. We also performed pilot experiments on ex vivo mouse cardiac muscle tissues with normal and genetically altered cardiomyocytes. Our results indicate this noncontact quantitative optical coherence elastographic method can be a useful tool for the cardiac muscle research and studies.
机译:我们提出了一种非接触评估心肌弹性的定量光学相干弹性成像方法。该方法基于剪切波成像光学相干断层扫描(SWI-OCT),其中使用聚焦气吹系统通过低压短时气流诱导局部组织变形,并使用相敏OCT系统以纳米级灵敏度监测诱导的组织移位的传播。 M模式OCT成像的一维扫描以及光学相位检索和映射技术的应用使得能够以超高帧频重建和可视化二维深度分辨剪切波在组织中的传播。与单轴压缩试验相比,采用估计的杨氏模量的模仿组织的模型证明了该方法在定量弹性测量中的可行性。我们还对具有正常和遗传改变的心肌细胞的离体小鼠心肌组织进行了先导实验。我们的结果表明,这种非接触式定量光学相干弹性成像方法可以成为心肌研究的有用工具。

著录项

  • 来源
  • 会议地点 San Francisco CA(US)
  • 作者单位

    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA,Department of Biomedical Engineering, University of Houston, 3605 Cullen Blvd., Houston, Texas 77204, USA;

    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA;

    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA;

    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA;

    Department of Biomedical Engineering, University of Houston, 3605 Cullen Blvd., Houston, Texas 77204, USA;

    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA;

    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA,Texas Heart Institute, 6720 Bertner Ave., Houston, Texas 77030, USA;

    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA,Department of Biomedical Engineering, University of Houston, 3605 Cullen Blvd., Houston, Texas 77204, USA;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号