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首页> 外文会议>Optical Coherence tomography and coherence domain optical methods in biomedicine XIX >Lateral Resolution Enhancement via Imbricated Spectral Domain Optical Coherence Tomography in a Maximum-a-Posterior Reconstruction Framework
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Lateral Resolution Enhancement via Imbricated Spectral Domain Optical Coherence Tomography in a Maximum-a-Posterior Reconstruction Framework

机译：通过最大后验重建框架中的嵌入式光谱域光学相干断层扫描提高横向分辨率

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摘要

The lateral resolution of a Spectral Domain Optical Coherence Tomography (SD-OCT) image is limited by the focusing properties of the OCT imaging probe optics, the wavelength range which SD-OCT system operates at, spherical and chromatic aberrations induced by the imaging optics, the optical properties of the imaged object, and in the special case of in-vivo retinal imaging by the optics of the eye. This limitation often results in challenges with resolving fine details and structures of the imaged sample outside of the Depth-Of-Focus (DOF) range. We propose a novel technique for generating Laterally Resolved OCT (LR-OCT) images using OCT measurements acquired with intentional imbrications. The proposed, novel method is based on a Maximum A Posteriori (MAP) reconstruction framework which takes advantage of a Stochastic Fully Connected Conditional Random Field (SFCRF) model to compensate for the artifacts and noise when reconstructing a LR-OCT image from imbricated OCT measurement. The proposed lateral resolution enhancement method was tested on synthetic OCT measurement as well as on a human cornea SD-OCT image to evaluate the usefulness of the proposed approach in lateral resolution enhancement. Experimental results show that applying this method to OCT images, noticeably improves the sharpness of morphological features in the OCT image and in lateral direction, thus demonstrating better delineation of fine dot shape details in the synthetic OCT test, as well as better delineation of the keratocyte cells in the human corneal OCT test image.
机译：光谱域光学相干断层扫描（SD-OCT）图像的横向分辨率受到OCT成像探针光学器件的聚焦特性，SD-OCT系统工作的波长范围，成像光学器件引起的球差和色差的限制，成像对象的光学特性，在特殊情况下，通过眼睛的光学系统进行视网膜内成像。这种局限性常常带来解决焦点深度（DOF）范围之外的成像样本的精细细节和结构的挑战。我们提出了一种新的技术，该技术可通过使用有意加成的OCT测量来生成横向分辨OCT（LR-OCT）图像。所提出的新颖方法基于最大后验（MAP）重建框架，该框架利用随机完全连接条件随机场（SFCRF）模型来补偿从基于OCT的固定测量重建LR-OCT图像时的伪影和噪声。拟议的横向分辨率增强方法在合成OCT测量以及人角膜SD-OCT图像上进行了测试，以评估拟议方法在横向分辨率增强中的有用性。实验结果表明，将该方法应用于OCT图像，可以显着提高OCT图像和横向的形态特征的清晰度，从而在合成OCT测试中更好地描绘出细微的点状细节，并更好地描绘出角膜细胞人角膜OCT测试图像中的细胞。

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